Infection in Patients with Severe Burns: Causes and Prevention Thereof

Smoke inhalation increases intensive care requirements and morbidity in paediatric burns

“…One theory of increased infection susceptibility in patients with isolated cutaneous burns alone is severe damage to the skin barrier causes global depression of local and systemic host cellular and humoral immune responses which then induces a state of immunosuppression that predisposes burn patients to infective complications [16]. A recent study found elevated levels of damage-associated molecular patterns (DAMPs) such as hyaluronic acid (HA), double-stranded DNA (dsDNA) in bronchial washings obtained within the first 72 h of injury were significantly associated with positive bacterial respiratory cultures obtained during the first 14 days after injury.…”

Nosocomial Infections in Iranian Pediatric Patients With Burn Injuries: A Review

“…Regarding etiologies of burn wound infection, a high resistance of P. aeruginosa, as a causative agent of NI, to the most of antimicrobial agents was reported (20,24,25). Azimi et al (2) identified more than one bacteria from the wounds in 95% of samples.…”

The impact of inhalation injury in patients with small and moderate burns

“…When the burn area is larger, systemic inflammation is more severe [16]. Severe immune deficits have been described among burn patients, including impaired cytotoxic T-lymphocyte response, myeloid maturation arrest causing neutropenia, impaired neutrophil function, and decreased macrophage production [17][18][19][20]. Global immunosuppression increases the rate of infection.…”