Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine
Abstract:Keywords: lipopeptide, adjuvant, live-attenuated virus vaccine, HRSV, paramyxovirusDevelopment of live-attenuated human respiratory syncytial virus (HrSV) vaccines has proven to be difficult. Several vaccine candidates were found to be over-attenuated and displayed limited immunogenicity. recently, we identified three synthetic cationic lipopeptides that enhanced paramyxovirus infections in vitro. the infection enhancement proved to be mediated by enhanced virus binding to target cells. We hypothesized that th… Show more
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