Infection by human papillomavirus types 6, 11, 16, 18, 31, 33 and 35 of the cervix in Japanese women

Abstract

Exfoliated cervical cells from 321 Japanese women were examined for human papillomavirus (HPV) DNA types 6, 11, 16, 18, 31, 33 and 35 using polymerase chain reaction (PCR) and dot-blot hybridization methods. HPV DNA was present in 9.3% of patients with normal cervixes, 72.7% of patients with cervical intraepithelial neoplasia (CIN) and 77.8% of patients with invasive carcinoma. Younger patients (</=29 years) with normal cervixes had a 18.5% incidence of HPV DNA, whilst similar older patients (>/=50 years) had a 1.9% incidence, a significant difference (chi2= 6.478, P < 0.01). In the CIN I and II groups, an incidence of 11.1% of types 16 and 18 was found, while in the CIN III or invasive carcinoma group the incidence was 58.1%, again a significant difference (chi2 = 12.075, P < 0.01). Furthermore, persistence or progression of CIN showed a significant correlation with infections by types 16 and 33 (chi2= 4.904, P < 0.01). However, no significantly different incidence of HPV infection was found between the CIN and the invasive carcinoma groups. It is suggested that (a) younger patients with normal cervixes have a higher incidence of HPV infection than do older patients; (b) HPV types 16, 18 and 33 are important etiologic agents of CIN III and invasive carcinoma, as well as in the persistence and progression of CIN; (c) progression of CIN to invasive carcinoma may depend on factors other than HPV infection in the cervix.

Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method

“…However, the second most common types in the current study were HPV‐18 and HPV‐58 (11.4%), and HPV‐31 and HPV‐45 were not detected in patients with carcinoma. The prevalence of HPV‐16 in patients with HSIL in the current study (51.9%) was comparable to its prevalence in other previous reports (43–72%) that used the PCR method 13–15. The next most common types in this study differed slightly from those reported in other studies.…”

“…The prevalence of HPV-16 in patients with HSIL in the current study (51.9%) was comparable to its prevalence in other previous reports (43-72%) that used the PCR method. [13][14][15] The next most common types in this study differed slightly from those reported in other studies. HPV-58, in addition to HPV-18, was the second most common type, whereas HPV-31 and HPV-35 were more frequent in other studies.…”

“…The next most common types in this study differed slightly from those reported in other studies. HPV‐58, in addition to HPV‐18, was the second most common type, whereas HPV‐31 and HPV‐35 were more frequent in other studies 14–16. However, a more recent study using a PCR/reverse blot‐strip assay17 reported that HPV 50s, including HPV‐51, HPV‐52, HPV‐56, and HPV‐58, were the most common HPV types after HPV‐16 in patients with dysplasia.…”

Urethral condyloma acuminata following urethral instrumentation in an elderly man

“…In particular, the prevalence of HPV types 6 and 11 were 3% and 15%, respectively. In Japan, HPV types 6, 11, 16, 18, 31, 33 and 35 were present in 9.3% of women with normal cervixes 2 …”

“…In Japan, HPV types 6, 11, 16, 18, 31, 33 and 35 were present in 9.3% of women with normal cervixes. 2 While the high prevalence of genital HPV in women is reported, there is little known regarding the prevalence in men. International Agency for Research on Cancer (IARC) investigators reported a high prevalence (3.5% -39.0%) of genital HPV in the penile skin of healthy men.…”