Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues

The Cell-Mediated Immune Response against Bovine alphaherpesvirus 1 (BoHV-1) Infection and Vaccination

“…During latency, IFN-λ3 RNA levels were significantly increased in all nervous tissues examined compared with un-infected control calves. During reactivation from latency, IFN-λ3 expression in the frontal and posterior cortex and cervical medulla of BoHV-1-infected calves were down-regulated relative to the control group [148]. Future studies should examine the role of type III IFN during BoHV-1 infection to better understand its antiviral activity and its potential application as a biotherapeutic agent.…”

“…IFN-λ3 levels in the nervous tissues (trigeminal ganglion, frontal cortex, posterior cortex, olfactory cortex, and cervical medulla) were examined in calves infected with BoHV-1 (Cooper strain) [148]. Increased IFN-λ3 levels were detected in the TG of acutely infected calves.…”

A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

“…49 Approximately 66% of individuals with diabetes suffer from peripheral neuropathy in their lower extremity. There are several factors responsible for neuropathy, namely, abnormalities in the metabolism of fatty acids, 50 pre-diabetes neuropathy, 51,52 protein kinase-C pathway activation, 53 myoinisitol, 54 formation of glycated end products, 55 production of neural tissues, 56 and production of growth factors. 57 DN is also influenced by peripheral axonal degeneration, decreased blood supply, nerve conduction and segmental demyelination, culminating in callus formation.…”