2012
DOI: 10.1186/1742-2094-9-95
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Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus

Abstract: BackgroundCongenital human cytomegalovirus (HCMV) infections can result in CNS abnormalities in newborn babies including vision loss, mental retardation, motor deficits, seizures, and hearing loss. Brain pericytes play an essential role in the development and function of the blood–brain barrier yet their unique role in HCMV dissemination and neuropathlogy has not been reported.MethodsPrimary human brain vascular pericytes were exposed to a primary clinical isolate of HCMV designated ‘SBCMV’. Infectivity was an… Show more

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Cited by 106 publications
(134 citation statements)
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“…During JEV infection, the permeability-inducing effect of IL-6 was supported by the finding of the inhibitory effect of IL-6 neutralizing antibody against JEV-conditioned medium-induced barrier disruption and the barrier-disrupting effect of exogenous recombinant IL-6. The corresponding compromised endothelial barrier integrity by infected pericytes and accompanying IL-6 production was also noted in cases of HIV-1 and human cytomegalovirus infection (22,23). In addition to macrophage-derived neutrophil chemotactic factor (15), our findings suggest that IL-6 released by brain microvascular endothelium neighboring pericytes is of paramount importance in Japanese encephalitis-associated BBB breakdown.…”
Section: Discussionmentioning
confidence: 75%
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“…During JEV infection, the permeability-inducing effect of IL-6 was supported by the finding of the inhibitory effect of IL-6 neutralizing antibody against JEV-conditioned medium-induced barrier disruption and the barrier-disrupting effect of exogenous recombinant IL-6. The corresponding compromised endothelial barrier integrity by infected pericytes and accompanying IL-6 production was also noted in cases of HIV-1 and human cytomegalovirus infection (22,23). In addition to macrophage-derived neutrophil chemotactic factor (15), our findings suggest that IL-6 released by brain microvascular endothelium neighboring pericytes is of paramount importance in Japanese encephalitis-associated BBB breakdown.…”
Section: Discussionmentioning
confidence: 75%
“…The regulation of BBB integrity by pericytes is of increasing interest due to the fact that these cells are in close proximity to brain endothelium and release a large number of endothelial permeability-regulating molecules. Pericytes are known to secrete elevated levels of permeability-inducing factors such as TNF-␣, IL-1␤, IL-6, metalloproteinases, and VEGF under different conditions (19)(20)(21)(22)24). These factors were elevated in JEV-infected animals and cultured glial cells (10,11,15,31,(37)(38)(39).…”
Section: Discussionmentioning
confidence: 95%
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“…This raises interesting questions in regards to a possible stromal progenitor cell reservoir for latent HCMV or at the very least an amplification reservoir. 46 Sundin et al 33 show that ex vivo-expanded hMSCs from HCMV seropositive individuals displayed no signs of viral infection as measured by PCR. ASCs are regarded as immunoprivileged and their residence in the body's largest endocrine organ would be an ideal site for HCMV to influence host health.…”
Section: Discussionmentioning
confidence: 99%
“…This protein represents the largest component in virus structure 14 . The expression of this protein coincides with viral ly c replica on 15 , also the expression of this protein refl ect the ac ve viral infec on 16 .…”
Section: Discussionmentioning
confidence: 81%