Infection and inflammation in sepsis

Šurbatović, Maja; Filipović, Nikola; Slavkovic, Zoran; Radaković, Sonja

doi:10.2298/vsp0602163s

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…The effects of cytokines are initiated by their binding to specific receptors at the membrane of target cell. This binding starts a cascade of events that leads to induction, enhancement, or inhibition of cytokine-regulated genes in the nucleus of the target cell, which results in modulation of cell immune activity [ 12 – 14 ].…”

Section: Some Of the New Elements Of Immunoinflammatory Response Imentioning

confidence: 99%

Immunoinflammatory Response in Critically Ill Patients: Severe Sepsis and/or Trauma

Šurbatović

Veljović

Jevdjić

et al. 2013

Mediators of Inflammation

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Immunoinflammatory response in critically ill patients is very complex. This review explores some of the new elements of immunoinflammatory response in severe sepsis, tumor necrosis factor-alpha in severe acute pancreatitis as a clinical example of immune response in sepsis, immune response in severe trauma with or without secondary sepsis, and genetic aspects of host immuno-inflammatory response to various insults in critically ill patients.

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Section: Some Of the New Elements Of Immunoinflammatory Response Imentioning

confidence: 99%

Immunoinflammatory Response in Critically Ill Patients: Severe Sepsis and/or Trauma

Šurbatović

Veljović

Jevdjić

et al. 2013

Mediators of Inflammation

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“…Many are proinflammatory, for example, tumor necrosis factor- (TNF-) α , interleukin- (IL-) 1, IL-8, and high-mobility group box- (HMGB-) 1, others are anti-inflammatory, for example, IL-10 and IL-1 receptor antagonist (ra) and some possess both activities, for example, IL-6. Cytokines act by binding to specific receptors at the target cell membrane, setting off a cascade that leads to induction, enhancement, or inhibition of number of cytokine-regulated genes in the nucleus, thereby modulating the immunological activity of the cell [2–4]. …”

Section: Complex Immune Response In Critically Ill Patients With Smentioning

confidence: 99%

Immune Response in Severe Infection: Could Life‐Saving Drugs Be Potentially Harmful?

Šurbatović

Jevdjić

Veljović³

et al. 2013

The Scientific World Journal

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“…Despite recent advances in the rapid dia gnosis and treatment of sepsis, the neurologic sequelae of severe sepsis remain poorly understood. Neurologic dysfunction in the form of ence phalopathy occurs frequently in patients with severe sepsis and is associated with increased morbidity and mortality (1)(2)(3)(4). Ischemic and hemorrhagic brain lesions are described in autopsied patients who died of sepsis and septic shock (5-7).…”

Section: Introductionmentioning

confidence: 99%

S-100β Protein in Patients with Severe Sepsis

Vučeljić¹,

Šurbatović²,

Vujanić³

2009

Journal of Medical Biochemistry

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Kratak sadr`aj: Uticaj sepse na mozak nije u potpunosti ra z ja{njen. U ovom radu, ispitivali smo vrednosti proteina S100b, kao biomarkera o{te}enja mozga, kod te{ke sepse. Cilj rada bio je da se utvrdi da li su vrednosti proteina S100b povi{ene na samom po~etku bolesti i da li se na osnovu njih mo`e predvideti ishod. Ispitano je 30 pacijenata sa te{kom sepsom, koji su bili podeljeni na pre`ivele (n=8) i umrle (n=22). Za analizu, uzimana je krv u prvih 24h od pojave simptoma. Koncentracija proteina S100b merena je pomo}u imunolo{kog testa meto dom elektrohemiluminiscencije (Elecsys 2010, Roche Dia g no stics). Tako|e, meren je i nivo C-reaktivnog proteina (CRP) imuno ne felometrijskim testom. Od 30 ispitanih pacijenata, 74,4% imalo je povi{ene vrednosti proteina S100b, dok je 25,6% imalo vrednosti u okviru referentnog opsega. Povi{ene vrednosti CRP imalo je svih 30 pacijenata. Izme|u pre `ivelih i umrlih nije bilo statisti~ki zna~ajne razlike u srednjoj vrednosti proteina S100b i CRP (0,390±0,515 vs. 0,415±0,508 mg/L; 98,76±69,94 vs. 161,68±118,38 mg/L). Korelacija izme|u proteina S100b i ishoda nije na|ena. Povi{ene vrednosti S100b ukazuju na verovatna difuzna okultna o{te}enja mozga, koja mogu biti i reverzibilna. Osim toga, protein S100b nije dovoljno pouzdan marker za rano predvi|anje ishoda kod pacijenata obolelih od te{ke sepse.Klju~ne re~i: o{te}enje mozga, C-reaktivni protein, sepsa, S100bSummary: The effects of sepsis on the brain are not fully elucidated. This study investigated the serum levels of S100b protein in severe sepsis, as a biomarker of brain damage. The aim was to determine whether the levels of S100b are increased early, at the onset of sepsis, and if this protein is a good early predictor of outcome. We studied 30 patients with severe sepsis, divided into the survivors (n=8) and norsurvivors (n=22). Blood was sampled within the first 24h after the onset of symptoms. The concentrations of S100b were measu red using an electrochemiluminiscence immu noassay (Elec sys 2010, Roche Diagno stics). Also, we measured the levels of C-reactive protein (CRP) using the immunonephelometric assay. Out of 30 patients, 74.4% had increased levels of S100b, while 25.6% had values within the reference range. A total of 30 patients had increased levels of CRP. The mean values of S100b and CRP did not differ significantly between the survi vors and nonsurvivors (0.390±0.515 vs. 0.415± 0.508 mg/L; 98.76±69.94 vs. 161.68±118.38 mg/L). Corre lation bet ween S100b and outcome was not found. The increased le vels of S100b indicate possible occult diffu se brain injury, that can be reversible. Moreover, the study sho wed S100b protein not to be a good early predictor of outcome in severe sepsis.

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Infection and inflammation in sepsis

Cited by 3 publications

References 22 publications

Immunoinflammatory Response in Critically Ill Patients: Severe Sepsis and/or Trauma

Immunoinflammatory Response in Critically Ill Patients: Severe Sepsis and/or Trauma

Immune Response in Severe Infection: Could Life‐Saving Drugs Be Potentially Harmful?

S-100β Protein in Patients with Severe Sepsis

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