Infection and inflammation in chronic rhinosinusitis: Gene ontology/pathway analysis perspective

Ramakrishnan, Vijay R.; Larson, Eric Stanley; Holt, Justin; Frank, Daniel N.

doi:10.1002/alr.23052

Cited by 1 publication

(2 citation statements)

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“…8 Although the specific pathogenesis of olfactory dysfunction in CRS patients has not been clarified, yet, studies have shown that it may be related to aging, immune factors, nasal polyps, genetic factors, and allergy. [9][10][11] In addition, the effects of metabolic related diseases such as obesity, hypertension, and dyslipidemia on CRS have been increasingly reported in recent years. [12][13][14][15] Metabolic syndrome (MS) refers to the pathological state of human metabolic disorder, which is, respectively, assessed using multiple indices to make the diagnosis: body mass index (BMI), blood pressure, cholesterol levels, high-density lipoprotein (HDL) levels, triglyceride levels, and fasting glucose levels.…”

Section: Introductionmentioning

confidence: 99%

“…Olfactory dysfunction is present in 56%–78% of CRS patients, 6,7 which seriously affects the quality of life of patients and increases the medical burden 8 . Although the specific pathogenesis of olfactory dysfunction in CRS patients has not been clarified, yet, studies have shown that it may be related to aging, immune factors, nasal polyps, genetic factors, and allergy 9–11 . In addition, the effects of metabolic related diseases such as obesity, hypertension, and dyslipidemia on CRS have been increasingly reported in recent years 12–15 …”

Section: Introductionmentioning

confidence: 99%

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Analysis of risk factors affecting olfactory dysfunction in patients with chronic rhinosinusitis: Highlighting the role of metabolic syndrome

Zhang

Wang

et al. 2023

Laryngoscope Investig Oto

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Objective This study aims to evaluate the relationship between chronic sinusitis (CRS) and metabolic syndrome (MS) in a Chinese population and to explore the risk factors for olfactory dysfunction in patients with CRS. Methods A total of 387 CRS patients were enrolled. Olfactory function was assessed by the Sniffin’ Sticks 12‐item test and MS was diagnosed according to the guidelines. Logistic regression analysis was performed on CRS patients to screen independent risk factors of olfactory dysfunction, adjusted for confounding factors. Results Among 387 patients, average age of visit and duration of onset were 48.7 years and 1.8 years, respectively. The prevalence of MS was 15.0%. CRS patients with MS were more likely to be older (51.2 vs. 46.8, p = .004), predominantly male (p < .001) and have a higher proportion of olfactory dysfunction (62.1% vs. 44.1%, p = .018) than those without MS. In multivariate logistic regression analysis, MS was associated with olfactory dysfunction in CRS patients (OR: 2.06, 95% CI: 1.14–3.72, p = .016). This association remained significant after controlling for confounding factors. In addition, nasal polyps (OR: 13.41, 95% CI: 8.11–22.17, p < .001) and allergic rhinitis (OR: 3.16, 95% CI: 1.67–5.99, p < .001) were also risk factors for olfactory dysfunction after adjusting for confounding factors. Conclusions MS is associated with olfactory dysfunction in patients with CRS. MS, nasal polyps, and allergic rhinitis are risk factors for olfactory dysfunction in CRS patients. Level of evidence IV

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