Infection and inflammation CF: Management of the basics upper airway diseases

Avaliação endoscópica nasal de crianças e adolescentes com fibrose cística

“…An important point is that although some studies have shown that up to 100% of CF patients had pansinusopathy evidenced on facial sinus computed tomography, 3,6,18,[20][21][22][23][24][25] 20% of these patients complained of no symptoms, and 36% had no alterations in the middle meati bilaterally. Other studies have also shown a lack of correlation between tomographic findings and clinical manifestations.…”

“…Altered salt and water flow result in loss of hydration of exocrine gland fluids and altered viscoelasticity of mucins. 5,6,18,19 Most patients with CF (over 90%) 3,6,18,[20][21][22][23][24][25] develop chronic and recurring rhinosinusitis, with or without nasal polyps. Altered mucus composition and viscoelasticity results in decreased mucociliary clearance and obstruction of paranasal sinus drainage ostia, facilitating local inflammation, hypoxia and increased carbon dioxide partial pressure.…”

“…[28][29][30] The frequency of nasal polyposis varies in different populations, and depends on the evaluation technique. 26,29,[31][32][33][34][35][36][37][38][39][40][41][42] It is thought that nasosinusal involvement may worsen pulmonary manifestations; 20 thus, otorhinolaryngologists have become more involved in evaluating these patients. Recent studies in Brazil 26,40,41 have shown a growing concern with characterizing in more detail the nasosinusal findings of CF patients, because this disorder is genetically very heterogeneous, with many types of mutations and a wide variety of clinical presentations, 28 which may be explained by specific phenotypic features of the Brazilian population and even within populations of any given region in this country.…”

Use of Sensor-Augmented Insulin Pump in Patient with Diabetes and Cystic Fibrosis: Evidence for Improvement in Metabolic Control

“…10,11 Additionally, CF patients are chronically infected and suffer frequent acute infectious exacerbations, which alter insulin sensitivity. 12 All these factors cause the course of diabetes associated with CF to be very unstable. To overcome these problems, several insulin regiments were proposed in the treatment of CFRD, including treatment with personal insulin pumps.…”

Nasal endoscopic evaluation of children and adolescents with cystic fibrosis

“…Most patients with CF (over 90%) 3 , 6 , 18 , 20 , 21 , 22 , 23 , 24 , 25 develop chronic and recurring rhinosinusitis, with or without nasal polyps. Altered mucus composition and viscoelasticity results in decreased mucociliary clearance and obstruction of paranasal sinus drainage ostia, facilitating local inflammation, hypoxia and increased carbon dioxide partial pressure.…”