Infecciones graves en pacientes con enfermedades autoinmunes tratados con ciclofosfamida

Cavallasca, Javier A.; Costa, Cecilia A.; Maliandi, María del Rosario; Contini, Liliana; Carrera, Elena; Musuruana, Jorge L.

doi:10.1016/j.reuma.2014.09.003

Cited by 24 publications

(3 citation statements)

References 9 publications

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“…CP is used to treat various types of cancer as a major component of cancer chemotherapy drugs (Pass et al, 2005). CP, on the contrary, can lead to immunosuppressive disorders such as infections, mortality, myelosuppression, and erythropoietin deficiencies (Cavallasca et al, 2015;Wang et al, 2009). The immunomodulatory action of CP results from the reductions of lymphocyte proliferation and cytokine productions by Th1 cells (IL-2, TNF-α, IL-12, and IFN-γ) and Th2 cells (IL-4) (Zhou et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

et al. 2021

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Aronia, a healthy fruit well known as black chokeberry, has health-promoting effects on hypertension, oxidative stress, and diabetes. Despite many reports of bioactivities of aronia, there is little scientific research on the potential for immune-enhancement.So, anthocyanin-fucoidan nanocomplex (AFNC, a nanocomplex of aronia extract and fucoidan) has been developed to improve immune-enhancement. This study aimed to identify immunomodulatory effects and underlying mechanisms of AFNC using RAW264.7 macrophages and cyclophosphamide-induced immunosuppressed mice.As a result, AFNC-treated RAW264.7 macrophages elevated the production of IL-2, IL-6, tumor necrosis factor (TNF)-α, and nitric oxide (NO). AFNC-enhanced inducible NO synthase expression via nuclear factor-κB signaling pathways. AFNC dosedependently increased levels of IL-2, IL-6, TNF-α, IL-10, IL-12, interferon-γ, or IL-4 in the serum and spleen of immunosuppressed mice. Taken together, AFNC encourages the immune-enhancing activity through immunostimulatory cytokine production by activation of macrophage. Therefore, these results suggest that AFNC is useful for immunodeficiency-related disorders. Practical applicationsIn these days of prevalence of infectious diseases, individual immunity is very important. AFNC has the immune-enhancing effects through immunostimulatory cytokine production by activation of macrophage. Therefore, AFNC could be widely applied to ameliorate a variety of diseases caused by immunosuppression such as infectious diseases.

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Section: Discussionmentioning

confidence: 99%

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

et al. 2021

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“…The risk of zoster was reportedly increased in 1465 systemic lupus erythematosus patients treated with prednisone [38] and in 60 patients with autoimmune diseases when corticosteroids were added to cyclophosphamide [39]; additional treatment with prednisone in 28,852 rheumatoid arthritis patients treated previously or currently with methotrexate increased the risk of zoster by 81 % [40]. Determining the role of corticosteroids on VZV antigen expression in GCA-positive and GCA-negative TAs in prior studies above was not possible since all TAs were de-identified.…”

Section: Corticosteroids and Vzv Vasculopathymentioning

confidence: 99%

Developments in Varicella Zoster Virus Vasculopathy

Nagel

Gilden

2016

Curr Neurol Neurosci Rep

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Varicella zoster virus (VZV) is a highly neurotropic human herpesvirus. Primary infection usually causes varicella (chicken pox), after which virus becomes latent in ganglionic neurons along the entire neuraxis. VZV reactivation results in zoster (shingles) which is frequently complicated by chronic pain (postherpetic neuralgia). VZV reactivation also causes meningoencephalitis, myelitis, ocular disorders, and vasculopathy, all of which can occur in the absence of rash. This review focuses on the association of VZV and stroke, and on the widening spectrum of disorders produced by VZV vasculopathy in immunocompetent and immunocompromised individuals, including recipients of varicella vaccine. Aside from ischemic stroke, VZV infection of cerebral arteries may lead to development of intracerebral aneurysms, with or without hemorrhage. Moreover, recent clinical-virological case reports and retrospective pathological-virological analyses of temporal arteries positive or negative for giant cell arteritis (GCA) indicate that extracranial VZV vasculopathy triggers the immunopathology of GCA. While many patients with GCA improve after corticosteroid treatment, prolonged corticosteroid use may potentiate VZV infection, leading to fatal vasculopathy in the brain and other organs.

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“…Consequently, the normal immune cells are also disproportionately affected, which in turn might increase the patient's susceptibility to infection [3,4]. Indeed, it has been reported widely by clinical studies that severe infection is the leading cause of death in patients with autoimmune diseases, which was partly due to the long-term usage of immunosuppressive drugs [5][6][7]. Thus, new drugs or therapy which is less deleterious to patients' normal immune responses is in urgent need.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cells Enhance Pulmonary Antimicrobial Immunity and Prevent Following Bacterial Infection

Chen

Huang

et al. 2020

Stem Cells International

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Background. Immunosuppressants such as cyclophosphamide (CTX) have been employed to treat a wide array of autoimmune diseases. The most unfavourable side effects of these drugs are their suppression on the antimicrobial immunity and increasing the risk of infection. As a promising substitution/adjunct, mesenchymal stem cells (MSCs) are currently being tested in several clinical trials. However, their influence on the recipients' antimicrobial immunity remains unclear. Methods. In this study, C57BL/6 mice were treated with either CTX or MSCs, and then both the innate and adaptive immunity of the lung were determined. To investigate the influence of CTX and MSCs on the immune defence against infection, the treated mice were intranasally infected with opportunistic pathogen Haemophilus influenzae (Hi). Bacterial clearance and antibacterial immune responses were analysed. Results. Our data showed that CTX strongly inhibited the proliferation of lung immune cells, including alveolar macrophages (AMs) and T cells, whereas MSCs increased the numbers of these cells. CTX suppressed the phagocytic activity of AMs; on the contrary, MSCs enhanced it. Notably, infusion of MSCs led to a remarkable increase of regulatory T cells and Th1 cells in the lung. When infected by Hi, CTX did not significantly impair the elimination of invaded bacteria. However, MSC-treated mice exhibited accelerated bacterial clearance and moderate inflammation and tissue damage. Conclusion. Our study reported that unlike traditional immunosuppressants, modulation of MSCs on the recipient's immune response is more elegant. It could preserve and even enhance the antimicrobial defence, suggesting that MSCs are better choice for patients with high risk of infection or those who need long-term immunosuppressive regimen.

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Infecciones graves en pacientes con enfermedades autoinmunes tratados con ciclofosfamida

Cited by 24 publications

References 9 publications

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

Developments in Varicella Zoster Virus Vasculopathy

Mesenchymal Stem Cells Enhance Pulmonary Antimicrobial Immunity and Prevent Following Bacterial Infection

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