Infección por Virus del Papiloma Humano y citología cérvico-vaginal en mujeres indígenas del Cañar, Ecuador.

Ordóñez, Julia Irma Carrión; Brito, Yudira Soto; Antúnez, Maritza Pupo; Loja-Chango, Rita

doi:10.21931/rb/2019.04.03.10

Cited by 7 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The frequency of HPV infection had unequal distribution between both group of women demonstrating marked social and cultural differences. Similar results have been also reported in the provinces of Guayas and Azuay from Ecuador [5,15] and in other world regions, indicating that HPV prevalence drastically vary among countries and even in the same country [25].…”

Section: Viral Load Of Hr-hpv Typessupporting

confidence: 85%

“…Quality control for Pap test was 100% satisfactory for samples adequacy, in both groups of studied women. There were differences at first Pap examination for both groups as previously reported [15,16]. From indigenous women 92% of samples were negative for malignity and 8% showed cy-tological changes.…”

Section: Pap Test Resultssupporting

confidence: 58%

“…In Ecuador, CC is one the most frequent cancers in women population where high-risk group are in women aged 30-64 years. Currently, there are few available studies about HPV epidemiology in Ecuador [9,15]. This study in women from Cañar province (indigenous and urban) revealed a series of cultural, socio-demographic, clinical and epidemiological factors which significantly relates to the presence and evolution of HPV infection.…”

Section: Discussionmentioning

confidence: 89%

“…Ecuadorian women began their sexual relationships after 20 years, although previous studies have reported 15 The high prevalence of HR-HPV infection suggests the necessity to incorporate Cañar population in CC early detection programs and to promote health campaigns in order to prevent SIT and improve sexual and reproductive education. Since these findings relied on small number of cases, further studies with large number of cases may be of significance to support these findings.…”

Section: Discussionmentioning

confidence: 99%

“…Studies in Ecuador have revealed dissimilar HPV genotype circulation patterns and some studies relate them with the incidence of cervical changes. Some province has reported as the most frequent HR-HPV (16,52,58,59) and LR-HPV (62, 71, 72 y 83) [15]. Meanwhile, others with predominance of genotypes 16 and 31 [30].…”

Section: Viral Load Of Hr-hpv Typesmentioning

confidence: 99%

See 4 more Smart Citations

Human Papillomavirus Infection and Associated Risk Factors in Indigenous and Urban Women from Cañar Province, Ecuador

Irma¹,

Yudira²,

Fabián³

et al. 2020

J Cervical Cancer Res

View full text Add to dashboard Cite

Background:There are few studies about the circulation of Human Papillomavirus (HPV) in Ecuadorian women from Cañar province.Objective: To determine HPV infection, circulating genotypes, viral load of the most frequent genotypes, intraepithelial cervical lesions and other cervical damages. Also, some social demographic, clinical and epidemiological behavior and its association with viral infection were analyzed.Methods: Two groups of Ecuadorian women were included, indigenous from rural region and urban women, both from Cañar province. A descriptive cross-sectional study was conducted from July 2017 to September 2018. Two hundred endocervical cytological samples were collected from both women populations between 15 and 55 years of age, residing in this province. Samples were analyzed by Papanicolaou test and mucosal cells were submitted to DNA extraction and subsequently HPV detection and genotyping using a commercial kit CLART® HPV 2 (Genomic, Spain). The viral load from more frequent genotypes was determined by qPCR using the commercial kit HPV Genotypes 14 Real-TM Quant (Sacace, Biotechnologies Srl. Italy). Results:Overall, infection frequency of HPV was 42.5% (85/200) with a predominance of oncogenic types, with a higher prevalence in women from urban area (51%). Cervical intraepithelial lesions were detected in 11% (22/200) of cases, mostly low-grade lesions (6%; 12/200). HPV31, 58, 66 and 59 were the most frequently HPV detected, however HPV16 was higher frequency in rural women. The high-risk HPV viral load was higher in urban women, except for HPV16. There were significant differences between the means of viral load values when high and low grade cervical lesions were compared. Smoking, hormonal contraceptive use, and a history of sexually transmitted infections were factors associated with viral infection (p < 0.05). Differences between risk factors were observed between rural and urban women. Conclusion:The high frequency of oncogenic HPV types detected indicates the need to incorporate the population of Cañar province into the early detection programs for cervical cancer and the vaccination program in Ecuador.

show abstract

Section: Viral Load Of Hr-hpv Typessupporting

confidence: 85%

Section: Pap Test Resultssupporting

confidence: 58%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Viral Load Of Hr-hpv Typesmentioning

confidence: 99%

See 3 more Smart Citations

Human Papillomavirus Infection and Associated Risk Factors in Indigenous and Urban Women from Cañar Province, Ecuador

Irma¹,

Yudira²,

Fabián³

et al. 2020

J Cervical Cancer Res

View full text Add to dashboard Cite

show abstract

Prevalence of human papillomavirus genotypes in women of different ethnicity from rural northwestern Ecuador

de los Ángeles Bayas-Rea,

Ponce,

Guenther

et al. 2024

BMC Global Public Health

View full text Add to dashboard Cite

Background In Ecuador, cervical cancer is the third most common cancer among women and the second most common cause of cancer-related death in women. Although HPV represents a serious public health problem worldwide, the information about its prevalence and genotypes in remote communities of Ecuador is limited. The aim of this study was to determine the distribution of HPV genotypes among ethnic minority women from two remote communities of the northwestern region of Ecuador: Afro-Ecuadorians and Chachis (Amerindian group). Methods We included 291 women who responded to a short survey and were screened for HPV by the amplification of the L1 gene and a nested multiplex PCR to detect 14 high risk (HR) genotypes. A survey collected information on ethnicity, age, community access, and sexual and gynecological history. We identified risk factors associated with HPV infection and co-infection using multivariate logistic regression to calculate odds ratio (OR) and Wald 95% confidence intervals (CI). Results Overall, HPV prevalence in the study cohort was 56%, and the five most common HR-HPV genotypes were HPV-58, -16, -68, -39, and -43; however, the distribution of HPV genotypes varied according to ethnicity. We identified lineage A (European variant) for HPV-16 and sublineage A2 for HPV-58 in both ethnic groups. Adjusting for ethnicity, age, community access, and number of sexual partners, we found that Afro-Ecuadorian women were less likely to have an HPV infection than Chachi women (OR: 0.49, 95% CI: 0.25, 0.96), and that participants in communities only accessible by river had 64% less chances of an HPV infection when compared to women in communities accessible by road (OR: 0.36, 95% CI: 0.19, 0.71), and women with 2 to 3 sexual partners had 2.47 times the odds of HPV infection than participants with 0–1 partners (OR: 2.47, 95% CI: 1.32, 4.6). Similar associations were observed with prevalence of co-infection. Conclusions This study provides baseline knowledge regarding the prevalence and distribution of HPV genotypes in ethnic groups of the northwestern coastal Ecuador and essential information for the implementation of appropriate HPV testing and vaccination program to prevent cervical cancer.

show abstract

High-risk HPV prevalence and vaccination coverage among Indigenous women in the Colombian Amazon: Implications for cervical cancer prevention. Cross-sectional study

Sarmiento-Medina,

de Amaya,

Villamizar-Gómez

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Cervical cancer, primarily caused by Human Papillomavirus (HPV) transmission through sexual contact, necessitates comprehensive strategies to combat its impact on women’s health. Yet, certain underserved populations, such as low socioeconomic and ethnic minority groups, encounter barriers in accessing timely interventions and early diagnosis. This cross-sectional study was conducted with the aim of assessing HPV prevalence, genotype distribution, and co-infections among 280 adult women residing in a Colombian Indigenous Reserve within the Amazon region. The research adhered to a community-centric approach that respected cultural norms, native languages, and Indigenous authorities’ permission. The study revealed an overall HPV infection prevalence of 31.1% (n = 87, 95% CI 25.7–36.8), with 22.5% (n = 63, 95% CI 17.7–27.8) of women infected by at least one high-risk HPV genotype and 15.0% (n = 42, 95% CI 11–19.7) infected by at least one LR genotype. These results align with the findings of other Colombian studies. Notable high-frequency genotypes included 16, 52, 66, 56, and 68, with the most common combinations being [66–52] and [66–58]. The study also assessed the prevalence of HPV vaccination, revealing a rate of 22.9%, lower than the national average. In vaccinated women, the prevalence of genotypes 16 and 18 was significantly reduced, as anticipated. Importantly, it was observed that 57.1% of all high-risk HPV infections could have been prevented with the use of the nonavalent vaccine. These findings underscore the critical need to enhance adherence to early cervical cancer detection and monitor positive cases to evaluate high-risk HPV persistence. Efforts should be directed toward continuing vaccination coverage against high-risk HPV 16 and 18 with the quadrivalent vaccine, while also striving to make the nonavalent vaccine accessible for inclusion in large-scale public health programs. Additionally, the study did not identify a specific pattern of co-infection. The study emphasizes the significance of adopting a locally tailored epidemiological approach to guide and promote cervical cancer prevention efforts in Indigenous communities.

show abstract

Infección por Virus del Papiloma Humano y citología cérvico-vaginal en mujeres indígenas del Cañar, Ecuador.

Cited by 7 publications

References 16 publications

Human Papillomavirus Infection and Associated Risk Factors in Indigenous and Urban Women from Cañar Province, Ecuador

Human Papillomavirus Infection and Associated Risk Factors in Indigenous and Urban Women from Cañar Province, Ecuador

Prevalence of human papillomavirus genotypes in women of different ethnicity from rural northwestern Ecuador

High-risk HPV prevalence and vaccination coverage among Indigenous women in the Colombian Amazon: Implications for cervical cancer prevention. Cross-sectional study

Contact Info

Product

Resources

About