Infección por SARS-CoV-2 asociada a diplopía y anticuerpos antirreceptor de acetilcolina

Álvarez, A.I. Pérez; Cuervo, C. Suárez; Menéndez, S. Fernández

doi:10.1016/j.nrl.2020.04.003

Cited by 18 publications

(8 citation statements)

References 6 publications

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“…Although our patients presented similar disorders to those reported in previous studies (headache, intracranial haemorrhage, stroke, encephalopathy, etc), 5 , 35 , 36 , 37 , 38 we found a significant number of patients with confusional syndrome and acute myopathy, which was most probably inflammatory (systemic reaction) or associated with critical illness polyneuropathy, rather than secondary to direct invasion by the virus. We believe that both complications are associated with the severity of COVID-19 in these patients.…”

Section: Discussionsupporting

confidence: 81%

Neurological complications in critical patients with COVID-19

Abenza-Abildúa¹,

Ramirez-Prieto²,

Moreno-Zabaleta³

et al. 2020

Neurología (English Edition)

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Introduction We analysed the neurological complications of patients with severe SARS-CoV-2 infection who required intensive care unit (ICU) admission. Patients and methods We conducted a retrospective, observational, descriptive study of consecutive patients admitted to the ICU due to severe respiratory symptoms secondary to SARS-CoV-2 infection between 1 April and 1 June 2020. Results We included 30 patients with neurological symptoms; 21 were men (72.40%), and mean age (standard deviation [SD]) was 57.41 years (11.61). The mean duration of ICU stay was 18.83 days (14.33). The neurological conditions recorded were acute confusional syndrome in 28 patients (93.33%), neuromuscular disease in 15 (50%), headache in 5 (16.66%), cerebrovascular disease in 4 (13.33%), and encephalopathies/encephalitis in 4 (13.33%). CSF analysis results were normal in 6 patients (20%). Brain MRI or head CT showed alterations in 20 patients (66.6%). EEG was performed in all patients (100%), with 8 (26.66%) showing abnormal findings. In 5 of the 15 patients with clinical myopathy, diagnosis was confirmed with electroneuromyography. We found a correlation between older age and duration of ICU stay ( P = .002; 95% CI, 4.032-6.022; OR:). Conclusions Severe COVID-19 mainly affects men, as observed in other series. Half of our patients presented acute myopathy, and almost all patients left the ICU with acute confusional syndrome, which fully resolved; no correlation was found with EEG or neuroimaging findings. Older age is associated with longer ICU stay.

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Section: Discussionsupporting

confidence: 81%

Neurological complications in critical patients with COVID-19

Abenza-Abildúa¹,

Ramirez-Prieto²,

Moreno-Zabaleta³

et al. 2020

Neurología (English Edition)

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“…Si bien nuestra serie describe la patología ya referida en otras publicaciones (cefaleas, hemorragias intracraneales, ictus, encefalopatías, etc.) 5 , 35 , 36 , 37 , 38 , hemos visto un número significativo de miopatías agudas miopatías agudas (posiblemente más inflamatorias como reacción secundaria sistémica, o críticas, que secundarias a una invasión directa del virus), y un número muy elevado de síndromes confusionales. Creemos que ambas complicaciones están relacionadas con la gravedad de la enfermedad de estos pacientes.…”

Section: Discussionunclassified

Complicaciones neurológicas en pacientes críticos por SARS-CoV-2

et al. 2020

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Introducción Nos proponemos analizar las complicaciones neurológicas de los pacientes con infección grave por SARS-CoV-2 que han requerido ingreso en unidad de cuidados intensivos (UCI). Pacientes y métodos Estudio descriptivo retrospectivo, observacional, de pacientes consecutivos ingresados en UCI por infección respiratoria grave por SARS-CoV-2 desde el 1 de abril hasta el 1 de junio de 2020. Resultados Registramos 30 pacientes con síntomas neurológicos, 21 hombres (72,40%), edad media: 57,41 años ± 11,61 desviación estándar (DE). Estancia media en UCI: 18,83 ± 14,33 DE. A nivel sindrómico: 28 pacientes (93,33%) con síndrome confusional agudo, 15 (50%) con patología neuromuscular, 5 (16,66%) con cefalea, 4 (13,33%) con patología cerebrovascular y 4 (13,33%) con encefalopatías/encefalitis. Punción lumbar normal en 6 pacientes (20%). La RMN craneal o TAC craneal mostró alteraciones en 20 casos (66,6%). Se realizó EEG en todos los pacientes (100%), alterado en 8 pacientes (26,66%). En 5 de los 15 pacientes con miopatía clínica se ha podido confirmar con ENMG. Hemos encontrado relación entre la mayor edad y los días de ingreso en UCI (p = 0,002; IC 95%: 4,032-6,022; OR: 3,594). Conclusiones La infección grave por COVID-19 afecta mayoritariamente a hombres, similar a lo descrito en otras series. La mitad de nuestros pacientes presenta una miopatía aguda, y casi la totalidad de los pacientes salen de la UCI con síndromes confusionales agudos que evolucionan a una resolución completa, sin correlacionarse con los resultados del EEG o de pruebas de neuroimagen. La mayor edad se asocia con un mayor número de días de estancia en UCI.

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“…Преходящая диплопия, ассоциированная с наличием антител к ацетилхолиновым рецепторам, описана А. Pérez с соавт. [162]. При пандемии больные с миастенией, синдромом Ламберта-Итона, другими нервно-мышечными заболеваниями [163][164][165] относятся к лицам с высоким риском заражения, отягощения соматического статуса, развития и прогрессирования дыхательной недостаточности.…”

Section: синдром гийена-барреunclassified

The Nervous System Damage in Covid-19 Patients

Белопасов

Samoilova

Baklaushev

2020

Journal of Clinical Practice

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Based on the available publications, the article systematizes the forms of damage to the central nervous system in СOVID-19patients. Along with a description of clinical manifestations, pathogenesis, methods of laboratory, instrumental and radiological diagnosis with the discussion of the nosological forms. An interdisciplinary approach and international cooperation are required to study the problems pathogenesis, course, outcomes, and the development of new methods of diagnosis and treatment.

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Infección por SARS-CoV-2 asociada a diplopía y anticuerpos antirreceptor de acetilcolina

Cited by 18 publications

References 6 publications

Neurological complications in critical patients with COVID-19

Neurological complications in critical patients with COVID-19

Complicaciones neurológicas en pacientes críticos por SARS-CoV-2

The Nervous System Damage in Covid-19 Patients

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