Infección por citomegalovirus humano

Gámez, Sara; Ruiz, Mercedes Pérez; Navarro-Marí, José María

doi:10.1016/s0213-005x(14)70145-4

Cited by 16 publications

(6 citation statements)

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“…Second, although we were unable to conclusively rule out sequential re-infections, we found that 3/3 bats sampled multiple times between 2015 and 2018 remained infected up to four years after initially being BHV-positive. Third, we observed bats with low levels of DrBHV in saliva (as indicated by lack of detectable virus DNA in round 1 of the PCR), which we hypothesise may have been sampled during the latent phase of infection 50 . If latency and reactivation are preserved in the vaccine vector, reactivations might naturally boost immune responses to VBRV over the course of the vaccinated bat’s lifetime, while potentially providing additional opportunities for vaccine transmission.…”

Section: Discussionmentioning

confidence: 90%

Epidemiology and biology of a herpesvirus in rabies endemic vampire bat populations

et al. 2020

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Rabies is a viral zoonosis transmitted by vampire bats across Latin America. Substantial public health and agricultural burdens remain, despite decades of bats culls and livestock vaccinations. Virally vectored vaccines that spread autonomously through bat populations are a theoretically appealing solution to managing rabies in its reservoir host. We investigate the biological and epidemiological suitability of a vampire bat betaherpesvirus (DrBHV) to act as a vaccine vector. In 25 sites across Peru with serological and/or molecular evidence of rabies circulation, DrBHV infects 80–100% of bats, suggesting potential for high population-level vaccine coverage. Phylogenetic analysis reveals host specificity within neotropical bats, limiting risks to non-target species. Finally, deep sequencing illustrates DrBHV super-infections in individual bats, implying that DrBHV-vectored vaccines might invade despite the highly prevalent wild-type virus. These results indicate DrBHV as a promising candidate vector for a transmissible rabies vaccine, and provide a framework to discover and evaluate candidate viral vectors for vaccines against bat-borne zoonoses.

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Section: Discussionmentioning

confidence: 90%

Epidemiology and biology of a herpesvirus in rabies endemic vampire bat populations

et al. 2020

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“…Cytomegalovirus belongs to the herpes viruses’ family and has a linear, double-stranded DNA [ 4 ]. The overall prevalence of CMV is high.…”

Section: Discussionmentioning

confidence: 99%

“…In developing countries, the prevalence is predicted to be approximately 90% [ 4 ]. This infection is most commonly transmitted horizontally through saliva, sexual intercourse, blood transfusion or through an organ transplantation; nevertheless, vertical transmission is possible as well [ 4 ]. Immunocompromised patients are at an increased risk of suffering from symptomatic CMV disease.…”

Section: Discussionmentioning

confidence: 99%

“…The primary infection is followed by a latent phase of infection and the virus can be reactivated at a future point in time, particularly in the case of an impairment of the immune system [ 4 ]. A seroconversion of the IgM combined with a low IgG avidity and the corresponding clinical findings confirm a recent (within the previous 4 months) CMV primary infection.…”

Section: Discussionmentioning

confidence: 99%

“…Asthenia, arthralgia, and fever are common in patients with a CMV infection, and laboratory findings typically include lymphocytosis and atypical lymphocytes. A slight impairment of the liver function with a small elevation of the transaminases occurs frequently as well [ 1 , 4 ]. However, in rare cases, severe complications can also occur in immunocompetent patients.…”

Section: Discussionmentioning

confidence: 99%

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Relevant pericardial effusion caused by cytomegalovirus infection in an immunocompetent patient: a case report

et al. 2018

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BackgroundCytomegalovirus infection is known to cause symptomatic disease in immunocompromised patients, while an infection in immunocompetent individuals normally causes few or no symptoms. We present the case of an immunocompetent adult patient with unexpected severe evolution.Case presentationAn otherwise healthy, 72-year-old Caucasian woman presented with complaints of progressive shoulder pain and dyspnoea on exertion. The blood test results showed elevated inflammation parameters and elevated hepatic transaminase levels. Radiologic examinations were carried out, and the computed tomography scan revealed a hepatomegaly and a chest X-ray showed evidence of a unilateral pleural effusion. A transthoracic echocardiography detected pericardial effusion with consecutive hemodynamic changes. Since it was considered that using ultrasound-guided pericardiocentesis could significantly increase the risk of liver injury due to hepatomegaly, a pericardial window was performed instead. Further investigation showed that our patient tested positive for an acute cytomegalovirus infection in the serologic tests. Laboratory findings included new evidence of immunoglobulin M seroconversion and high immunoglobulin G avidity, so we considered the possibility that a former cytomegalovirus infection may be coexisting with a new cytomegalovirus reinfection.ConclusionsIn immunocompetent individuals, a symptomatic cytomegalovirus primary infection or reinfection should be considered in patients presenting with pericardial effusion and serositis.

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