Infección en pacientes neutropénicas sometidas a trasplante autólogo de progenitores hematopoyéticos por cáncer de mama

Palau, J.A. Escobedo; Picón, Isabel; Climent, Miguel Ángel; Martí, Roberto; Aznar, Eduardo Orduña; Sanjuán, M. Carmen; Máiquez, J.

doi:10.1016/s0213-005x(01)72685-7

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…La intensidad y duración de la neutropenia se conoce desde hace tiempo como uno de los principales factores relacionados con un riesgo incrementado de infección (2)(3)(4)(5)14). En nuestra serie la duración de la neutropenia es menor que la observada en otras series publicadas (1,5,10), en su mayor parte superior a 10 días.…”

Section: Discussionunclassified

“…We have observed a slightly higher incidence of gram negative pathogens. inserción de catéteres venosos centrales, déficit nutricional, hipotensión, deshidratación y de manera especial la intensidad y duración de la neutropenia provocado por el tratamiento citostático (2)(3)(4)(5)(6). En estos pacientes existen además alteraciones en los mecanismos de inmunidad humoral y celular secundarios tanto al tratamiento aplicado como a la enfermedad subyacente (1).…”

Section: Abstract Background: Autologous Peripheral Blood Stem Cell Tunclassified

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Incidencia de episodios febriles en pacientes con mieloma múltiple sometidos a trasplante autólogo de progenitores hematopoyéticos de sangre periférica (TASPE)

Fernández‐Mosteirín

Salvador-Osuna

Lozano

et al. 2005

An. Med. Interna (Madrid)

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Section: Discussionunclassified

Section: Abstract Background: Autologous Peripheral Blood Stem Cell Tunclassified

Incidencia de episodios febriles en pacientes con mieloma múltiple sometidos a trasplante autólogo de progenitores hematopoyéticos de sangre periférica (TASPE)

Fernández‐Mosteirín

Salvador-Osuna

Lozano

et al. 2005

An. Med. Interna (Madrid)

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Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukemia

Kern

Klose

Jellen-Ritter

et al. 2005

Eur J Clin Microbiol Infect Dis

132

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The aim of the present study was to investigate the epidemiologic evolution of fluoroquinolone resistance of E. coli clinical isolates from patients admitted to a hematology-oncology service where fluoroquinolone prophylaxis during neutropenia was recommended as the standard of care for many years but was then discontinued in a trial conducted in patients with acute leukemia. Fluoroquinolones had been shown to decrease the incidence of gram-negative bacteremia in cancer patients with neutropenia, yet it was thought that the emergence of resistance in Escherichia coli and other gram-negative bacteria may have caused a progressive lack of efficacy of fluoroquinolone prophylaxis. Epidemiologic surveillance of fluoroquinolone resistance of E. coli clinical isolates at our cancer center since 1992 showed a continuing influx of new clones not previously observed in the population of cancer patients, an increase in the number of cancer patients per year colonized and/or infected by fluoroquinolone-resistant E. coli (1992-1994, 10-16 patients; 1995-1997, 24-27 patients), and a resistance rate of >50% among E. coli bloodstream isolates of hematology-oncology patients. A 6-month fluoroquinolone prophylaxis discontinuation intervention trial in 1998 suggested that despite increasing resistance among E. coli isolates, fluoroquinolone prophylaxis in acute leukemia patients was still effective in the prevention of gram-negative bacteremia (incidence rates, 8% during the pre-intervention period vs. 20% after discontinuation; p<0.01). The resumption of fluoroquinolone prophylaxis in acute leukemia patients thereafter decreased the incidence of gram-negative bacteremia to the pre-intervention level (9%; p=0.03), while the proportion of in vitro fluoroquinolone resistance in E. coli bacteremia isolates again increased (from 15% during the intervention period to >50% in the post-intervention period). Relative rates of resistance thus were a poor indicator of the potential clinical benefits associated with fluoroquinolone prophylaxis in cancer patients.

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Estudio prospectivo y controlado, no aleatorizado, de tres cohortes sobre la efectividad de dos pautas antibióticas, levofloxacino y contrimoxazol, en profilaxis antibacteriana de pacientes neutropénicos

et al. 2003

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Infección en pacientes neutropénicas sometidas a trasplante autólogo de progenitores hematopoyéticos por cáncer de mama

Cited by 3 publications

References 33 publications

Incidencia de episodios febriles en pacientes con mieloma múltiple sometidos a trasplante autólogo de progenitores hematopoyéticos de sangre periférica (TASPE)

Incidencia de episodios febriles en pacientes con mieloma múltiple sometidos a trasplante autólogo de progenitores hematopoyéticos de sangre periférica (TASPE)

Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukemia

Estudio prospectivo y controlado, no aleatorizado, de tres cohortes sobre la efectividad de dos pautas antibióticas, levofloxacino y contrimoxazol, en profilaxis antibacteriana de pacientes neutropénicos

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