Infección del tracto urinario por Escherichia Coli resistente a antibióticos tratada con Vaccinium Macrocarpon (arándano rojo): reporte de caso

Abstract

RESUMENEl Vaccinium macrocarpon (arándano rojo) tiene alguna evidencia que puede ayudar a prevenir las infecciones del tracto urinario (ITU); sin embargo, la información es limitada si se trata del uso de este producto en el tratamiento de las ITU. Se presenta el caso de una mujer de 42 años de edad con antecedentes de ITU a repetición y con episodio activo, que presenta urocultivo positivo a E. coli resistente a fluoroquinolonas, aminoglucósidos y cefalosporinas de segunda generación. La paciente acepta tomar tratamiento con polvo estandarizado de Vaccinium macrocarpon durante 20 días. Se evidenció resolución del cuadro clínico y adecuada respuesta bacteriológica a dicho suplemento, según controles a los 6, 16, 65 y 93 días postratamiento. Este reporte podría ser el primer paso para ampliar los estudios sobre el uso de productos derivados de Vaccinium macrocarpon para tratamiento de episodios de ITU resistente a antibióticos. Palabras clave: infecciones urinarias; Escherichia coli; Vaccinium macrocarpon; Resistencia Microbiana a Medicamentos (Fuente: DeCS). URINARY TRACT INFECTION CAUSED BY ANTIBIOTIC-RESISTANT Escherichia coli TREATED WITH Vaccinium macrocarpon (cranberry): A CASE REPORT ABSTRACTThere is some evidence that Vaccinium macrocarpon (cranberry) may help prevent urinary tract infections (UTI); however, the information about its use in the treatment of UTI is limited. A case of a 42 -year-old woman with a history of UTI and an active episode with positive E. coli urine culture, resistant to fluoroquinolones, aminoglycosides and 2nd generation cephalosporins. The patient accepts take a treatment with Vaccinium macrocarpon powder for 20 days. The resolution of clinical symptoms and an adequate bacteriological response were evidenced in the 6, 16, 65 and 93 days post-treatment controls. This report could be the first step to future studies on the use of products derived from Vaccinium macrocarpon for treatment of antibiotic-resistant episodes of UTI

Avaliação in Vitro Do Extrato De Cranberry Em Cepas Isoladas De Exames De Urina De Rotina Na Terceira Idade

“…O tratamento oferecido foi com o extrato em pó do fruto de Vaccinium macrocarpon 2 vezes ao dia durante 20 dias. Após seis dias de tratamento com cranberry, a paciente relatou estar assintomática, com sedimento urinário normal e urocultura negativa (VENTURA, 2016).…”

Cranberry Effects in Urinary Tract Infections

“…In Latin America, high percentages of E. coli strains were found to be resistant to fluoroquinolones (17.5-18.9%), ampicillin (61.4%), amoxicillin, clavulanic acid (18.6%), ceftriaxone (20.5%), gentamycin (25.0%), and trimethoprim/sulfamethoxazole (45%) [32].…”

“…In these circumstances, one of the most studied alternative therapies against UTIs is the treatment with V. macrocarpon [32]. Salo et al [35] have brought to light that anthocyanidins and proanthocyanidins found in cranberries are tannins with a natural defense function against microbial cells, and are a source of high-quality antioxidants.…”

“…Ventura [32] has shown the report of a patient who has suffered from recurring urinary infections for 20 years and made use of oral Ciprofloxacin for three days, later finding out they had E. coli following urine culture and resistance to the antibiotic they were using. Therefore, it was suggested to the patient to have treatment with cranberry extract.…”

“…The treatment described by Ventura [32] consisted of the intake of 5 g of the fruit, the equivalent amount to 18 mg of proanthocyanidins, dissolved in 250 mL of water, twice a day for 20 days, with follow-up attention. Six days after the end of treatment, the patient was asymptomatic, urine culture was normal, and antibiogram was negative.…”