Infecção em humanos por varíola bovina na microrregião de Itajubá, Estado de Minas Gerais: relato de caso

Silva, Afonso Carlos da; Reis, Bruno Borges; Ricci, José Eugênio Rios; Fernandes, Fabiana Sirolli; Corrêa, José Fabio; Schatzmayr, Hermann G.

doi:10.1590/s0037-86822008000500015

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Similar clinical symptoms were observed in humans beings in outbreaks described in other Brazilian states (Nagasse--Sugahara et al 2004, Megid et al 2008, Silva et al 2008, Schatzmayr et al 2009b). Sudoresis, anorexia, toxemia and lymph node swelling were also observed in some human cases (Silva et al 2008, Schatzmayr et al 2009a, 2009b. In comparison with other zoonotic vesicular disease, VACV infection appears to affect more severely and systematically the humans that have contact with the affected cattle (Büttner & Rziha 2002, Silva-Fernandes et al 2009).…”

Section: Discussionsupporting

confidence: 83%

“…VACV infection is zoonotic and transmission to man usually occurs through handling or milking affected cows (Smith 2007). Lesions in VACV-infected cattle are most frequently observed in teats and udders of milking cows, and in the mouth of suckling calves (Leite et al 2005, Silva et al 2008. In man, skin lesions are painful and occur mainly on the hands and fingers: nodular swellings, papules, pustules, ulcers and scabs.…”

Section: Introductionmentioning

confidence: 99%

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Outbreaks of vesicular disease caused by Vaccinia virus in dairy cattle from Goiás State, Brazil (2010-2012)

Sant’Ana

Leal²,

Rabelo³

et al. 2013

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 33 (7) Midwestern Brazil (2010, involving a total of 122 cows, 12 calves and 11 people. Dairy cows (3 to 9 years old) were affected in all cases and calves (2 to 9 months old) were affected in five outbreaks, presenting oral lesions. The morbidity ranged between 8 and 100% in cows, and 1.5 to 31% in calves. In the cows, the clinical signs started with vesicles (2-7mm), painful and coalescent papules (3-8 mm), which resulted in ulcers (5-25mm) and scabs in teats, and, occasionally, in the muzzle. The clinical course lasted from 16 to 26 days. The histopathology of bovine skin samples revealed superficial perivascular inflammatory infiltrate of lymphocytes, plasma cells, neutrophils, macrophages and multifocal areas of acanthosis, spongiosis, hipergranulosis and parakeratotic or orthokeratotic hyperkeratosis with adjacent focally extensive ulcers. Eosinophilic inclusion bodies were noted in the cytoplasm of the keratinocytes. PCR to vgf gene of Orthopoxvirus was positive in samples collected from all outbreaks, and in some cases, genomic VACV sequences were identified by nucleotide sequencing of the PCR amplicons. Infectious virus was isolated in cell culture from scabs from one outbreak. Antibodies to Orthopoxvirus were detected in at least 3 or 4 animals in most outbreaks, by ELISA (outbreaks 1, 2, 3, 4, 5 and 7) or virus-neutralization (outbreak 6). Neutralizing titers ranging from 8 to 64 in outbreak 6. In all outbreaks, VACV infection was suspected based on the clinical and pathological findings and it was confirmed by laboratory tests. Upon the etiological confirmation, other agents associated with vesicular disease were discarded. In all outbreaks, at least one milker who handled the affected cows developed malaise, headache, fever, painful vesico-pustular lesions mainly in the hands, but also in the neck and nose. These results confirm the circulation of VACV in the region and call attention for a correct diagnosis and the adoption of prophylactic and control measures.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Outbreaks of vesicular disease caused by Vaccinia virus in dairy cattle from Goiás State, Brazil (2010-2012)

Sant’Ana

Leal²,

Rabelo³

et al. 2013

Pesq. Vet. Bras.

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“…In humans, the clinical manifestations of BV are mainly lesions located at the primary site of infection, usually on the fingers and hands of milkers who have a history of unprotected contact with infected animals [12,14,15,17]. However, additional lesions as a result of the self-inoculation process have also been described in other body sites such as the face, eyes, and genital region, and in humans, BV is associated with high morbidity [18][19][20][21]. The process between the onset of the initial symptoms and the healing of the ulcerative skin lesions takes approximately 21 days.…”

Section: Introductionmentioning

confidence: 99%

Twenty Years after Bovine Vaccinia in Brazil: Where We Are and Where Are We Going?

et al. 2021

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Orthopoxvirus (OPV) infections have been present in human life for hundreds of years. It is known that Variola virus (VARV) killed over 300 million people in the past; however, it had an end thanks to the physician Edward Jenner (who developed the first vaccine in history) and also thanks to a massive vaccination program in the 20th century all over the world. Although the first vaccine was created using the Cowpox virus (CPXV), it turned out later that the Vaccinia virus was the one used during the vaccination program. VACV is the etiological agent of bovine vaccinia (BV), a zoonotic disease that has emerged in Brazil and South America in the last 20 years. BV has a great impact on local dairy economies and is also a burden to public health. In this review, we described the main events related to VACV and BV emergence in Brazil and South America, the increase of related scientific studies, and the issues that science, human and animal medicine are going to face if we do not be on guard to this virus and its disease.

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“…No rebanho as lesões usualmente têm aspecto vesicular, provocadas por diversos vírus, sendo mais frequentes por vírus cowpox, vaccinia, herpes e a papilomatose. No Brasil, o agente etiológico mais comum é o Vaccinia virus (Silva et al, 2008) e ocorre aumento dos surtos principalmente no período seco, época de maior traumatismo no úbere e tetas, favorecendo a disseminação do vírus no rebanho e também sugerindo uma sazonalidade da doença (Paredes, García, & Figueroa, 2006).…”

Section: Discussionunclassified

Nódulos do ordenhador: um relato de caso

Silva

Batista

Macedo

et al. 2020

RSD

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Nódulos do ordenhador é uma dermatovirose causada por vírus da família Poxviridae, que acometem o homem e animais. Em humanos, apresenta-se em forma progressiva com lesões maculopapulares de base eritematosa passando por formato de alvo, nódulo exsudativo, regenerativo, papilomatoso e cicatricial com crosta. O estudo objetivou descrever um Relato de Caso que contribuirá para conhecimento multiprofissional de saúde nas especialidades infecto-dermatológicas que apresentem manifestações cutâneas semelhantes, a fim de ampliar diagnósticos diferenciais. Trata-se de um estudo retrospectivo, descritivo e observacional no formato de Relato de Caso de um paciente que esteve internado no Hospital de Doenças Tropicais da Universidade Federal do Tocantins (HDT-UFT), localizado no município de Araguaína -TO. Os dados foram coletados por meio de prontuário médico eletrônico e relatório dos profissionais de saúde que realizaram o atendimento, após liberação do Comitê de Ética em Pesquisa da instituição hospitalar e assinatura do Termo de Consentimento Livre e Esclarecido, autorizando a divulgação do trabalho e imagens de forma que não cause constrangimentos ao participante. O paciente apresentou manifestações de lesões clássicas na região palmar, mas com presença também no couro cabeludo e joelho, cujos testes histopatológicos não foram realizados pelas limitações do serviço hospitalar; é importante que os médicos compreendam as formas cutâneas desta doença viral, realizar o tratamento ideal e orientar medidas preventivas de infecção secundária. Deve existir um maior aprofundamento quanto à temática com implementação de medidas de controle pelos órgãos responsáveis pela fiscalização da saúde dos animais bovinos e caprinos leiteiros visando combater o contágio em humanos.

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Infecção em humanos por varíola bovina na microrregião de Itajubá, Estado de Minas Gerais: relato de caso

Cited by 8 publications

References 12 publications

Outbreaks of vesicular disease caused by Vaccinia virus in dairy cattle from Goiás State, Brazil (2010-2012)

Outbreaks of vesicular disease caused by Vaccinia virus in dairy cattle from Goiás State, Brazil (2010-2012)

Twenty Years after Bovine Vaccinia in Brazil: Where We Are and Where Are We Going?

Nódulos do ordenhador: um relato de caso

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