Infants of mothers receiving gold therapy

Cohen, Daniel L.; Orzel, Joanna; Taylor, Andrew

doi:10.1002/art.1780240120

Cited by 44 publications

(5 citation statements)

References 4 publications

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“…Gold crosses the human placenta and is deposited in fetal tissues: concentrations of gold in umbilical cord serum of a term neonate whose mother received sodium aurothiomalate throughout pregnanc y were similar to those found in patients receiving this compound (Cohen et al 1981). Gold crosses the human placenta and is deposited in fetal tissues: concentrations of gold in umbilical cord serum of a term neonate whose mother received sodium aurothiomalate throughout pregnanc y were similar to those found in patients receiving this compound (Cohen et al 1981).…”

Section: Use In Pregnancysupporting

confidence: 61%

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Adverse Reactions With Oral and Parenteral Gold Preparations

Tozman

Gottlieb

1987

Medical Toxicology

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Auranofin (triethylphosphine gold), an oral gold preparation, has recently been made available, and along with injectable gold preparations, is of therapeutic value for rheumatoid arthritis. Serious gold toxicity is uncommon, and drug-related deaths rare. Many potential adverse reactions are similar, including dermatitis, stomatitis, thrombocytopenia, leucopenia, and proteinuria, generally with increased incidence in the injectable gold-treated patients. Oral gold is associated with benign lower gastrointestinal side effects, including diarrhoea, loose stools and abdominal cramps that are often dose-related and resolve spontaneously. The incidence of severe reactions such as thrombocytopenia, aplastic anaemia and exfoliative dermatitis is lower with oral gold than injectable preparations, and contributes to a superior risk-benefit ratio. The treatment of gold toxicity depends on the type and extent of organ involvement.

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Section: Use In Pregnancysupporting

confidence: 61%

“…One woman treated with monthly injections of sodium aurothiomalate 100mg throughout gestation had an uncomplicated pregnancy and normal baby (Cohen et al 1981). One woman treated with monthly injections of sodium aurothiomalate 100mg throughout gestation had an uncomplicated pregnancy and normal baby (Cohen et al 1981).…”

Section: Use In Pregnancymentioning

confidence: 99%

Adverse Reactions With Oral and Parenteral Gold Preparations

Tozman

Gottlieb

1987

Medical Toxicology

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“…The decision to breast feed appeared justifiable because the mother wished to, her other infants had developed allergy to artificial milk, the dose of gold was low, the infant was well despite exposure throughout pregnancy, and was closely monitored. Gold injected as thiomalate is cleaved from the parent molecule, distributes to body tissues and fluids, and is known to cross the placenta (Cohen et al, 1981). Published data suggest that the concentration-time profiles are not concurrent in serum and milk (Ostensen et al, 1988;Rooney et al, 1987), a finding which is borne out in the present case.…”

Section: Discussionsupporting

confidence: 49%

Use of sodium aurothiomalate during lactation.

Bennett

Humphries

Osborne

et al. 1990

Brit J Clinical Pharma

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The report concerns a mother who breast fed her infant whilst receiving sodium aurothiomalate for the treatment of rheumatoid arthritis. The milk:serum concentration ratio was not constant, reflecting the non‐ concurrence of the concentration‐time profiles of gold in milk and maternal serum after i.m. injection. Gold was detected in the infant's serum. Calculations indicate that the weight‐adjusted dose to the infant exceeded that received by the mother.

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“…Pregnancy: Fetal Effects. Gold compounds cross the placenta 77,78 and have been found in the fetal liver and kidneys. There is no evidence of an increase in neonatal malformations in the small number of pregnancies reported.…”

Section: Goldmentioning

confidence: 99%

The Effects of Immunosuppressive and Anti-inflammatory Medications on Fertility, Pregnancy, and Lactation

Janssen¹

2000

Archives of Internal Medicine

244

136

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Many rheumatic diseases affect women of childbearing age, and the medications used to treat these diseases may affect conception, pregnancy, fetal development, and lactation. Physicians who care for these women need to be aware of the potential adverse effects of these medications, and which medications can be used safely prior to conception and during pregnancy and lactation. Although reviews of individual classes of medications are available, there is no practical and comprehensive review that summarizes all of this information, and includes anticoagulant drugs and 2 recently approved drugs for rheumatoid arthritis. Women who take cytotoxic drugs should be informed of the risks of impaired fertility and congenital malformations, and must use effective methods of contraception. During pregnancy, nonsteroidal anti-inflammatory agents may be used until the last 6 weeks, and low to moderate doses of corticosteroids are safe throughout pregnancy. Among the disease-modifying agents, sulfasalazine and hydroxychloroquine treatment may be maintained. Cytotoxic drugs may be used after the first trimester to treat life-threatening disease. During lactation, prednisone, sulfasalazine, and hydroxychloroquine may be used cautiously. Women using heparin for treatment of antiphospholipid antibody syndrome should take measures to prevent bone loss. Men taking methotrexate, sulfasalazine, cyclosporine, azathioprine, or leflunomide should be apprised of the possibilities of infertility and teratogenicity.

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Infants of mothers receiving gold therapy

Cited by 44 publications

References 4 publications

Adverse Reactions With Oral and Parenteral Gold Preparations

Adverse Reactions With Oral and Parenteral Gold Preparations

Use of sodium aurothiomalate during lactation.

The Effects of Immunosuppressive and Anti-inflammatory Medications on Fertility, Pregnancy, and Lactation

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