Infantile nephrotic syndrome and congenital glaucoma

Kari, Jameela A.; Bamashmous, Hussain; Lingawi, Sattam S.; Al‐Sabban, Essam; Akhtar, Mohammed

doi:10.1007/s004670100669

Cited by 5 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DDD has been reported as a cause of SRNS in young children [30, 31] and in infants [32] but not as a cause of CNS. We had one patient who presented at one year of age with NS and biopsy revealed membranous histopathology.…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological correlations of congenital and infantile nephrotic syndrome over twenty years

et al. 2014

View full text Add to dashboard Cite

BackgroundNephrotic syndrome (NS) presenting early in life is caused by heterogeneous glomerular diseases. We retrospectively evaluated whether histological diagnosis in children presenting with NS in the first year of life predicts remission or progression to end-stage kidney disease (ESKD).MethodsThis is a single centre retrospective review of all children diagnosed with NS before one year of age between 1990 and 2009. All subjects had a renal biopsy, which was independently blindly reviewed by a single renal pathologist for the purpose of this study.ResultsForty-nine children (25 female) who presented at 0.1–11.6 (median 1.6) months were included with 31 presenting within the first three months of life. Histopathological review diagnostic categories were; 13 Mesangial proliferative glomerulopathy (MesGN), 12 Focal and segmental glomerulosclerosis (FSGS), 11 Finnish type changes, eight Diffuse Mesangial Sclerosis (DMS), three Minimal change disease (MCD) and one each of Dense Deposit Disease (DDD) and Membranous nephropathy. Two children died from haemorrhagic complications of the biopsy. Eight children achieved remission (four MesGN, one Finnish type changes, one FSGS, one MCD and one membranous) with patient and renal survival of 73 % and 43 %, respectively, at follow-up duration of 5–222 (median 73) months (with five lost to follow-up). All children with Finnish-type histopathological changes presented within five months of age. Due to the historical nature of the cohort, genetic testing was only available for 14 children, nine of whom had an identifiable genetic basis (seven NPHS1, one PLCE1 and one ITGA3) with none of these nine children achieving remission. All of them had presented within four months of age and required renal replacement therapy, and two died.ConclusionsHistopathological findings are varied in children presenting with NS early in life. Whilst groups of histological patterns of disease are associated with differing outcomes, accurate prediction of disease course in a specific case is difficult and more widespread genetic testing may improve the understanding of this group of diseases and their optimal management

show abstract

Section: Discussionmentioning

confidence: 99%

Clinico-pathological correlations of congenital and infantile nephrotic syndrome over twenty years

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Most cases of MPGN type II in fact progress to end-stage kidney disease [7] . Although there are isolated reports of MPGN in a 15-month-old male toddler [8] and on an 8-month-infant [9] , to the best of our knowledge there are no reports in patients as early as 2 months of life.…”

Section: Introductionmentioning

confidence: 99%

Advanced membrano - proliferative glomerulonephritis in a 2-month-old Nigerian male infant: A case report

C.C

S.N

et al. 2015

CRIM

View full text Add to dashboard Cite

Introduction: Membrano-proliferative glomerulonephritis (MPGN) is rare in infancy and remains an uncommon cause of chronic nephritis which primarily affects children and young adults. Case presentation:The index case is a 2-month-old male infant who presented with vomiting, generalized body swelling and anuria following ingestion of some parent-prescribed drugs. Following mortality on the 28th day of admission, a post-mortem evaluation revealed an advanced MPGN: a histological picture best described as "a 2-month-old with the kidneys of a 70-year-old". Conclusion:The case report aims to underscore the possibility of MPGN in early infancy albeit rare. It also highlights the need for a high index of suspicion in cases of unexplained acute renal failure especially in settings where there are limited facilities for diagnosis.

show abstract

Pediatric renal diseases in the Kingdom of Saudi Arabia

Kari

2012

World J Pediatr

View full text Add to dashboard Cite

show abstract

Infantile nephrotic syndrome and congenital glaucoma

Cited by 5 publications

References 17 publications

Clinico-pathological correlations of congenital and infantile nephrotic syndrome over twenty years

Clinico-pathological correlations of congenital and infantile nephrotic syndrome over twenty years

Advanced membrano - proliferative glomerulonephritis in a 2-month-old Nigerian male infant: A case report

Pediatric renal diseases in the Kingdom of Saudi Arabia

Contact Info

Product

Resources

About