Infantile hepatic hemangioendothelioma successfully treated by low dose of propranolol

Mâaloul, I.; Aloulou, Hajer; Hentati, Yosr; Kamoun, Thouraya; Mnif, Z.; Hachicha, M.

doi:10.1016/j.lpm.2017.01.010

Cited by 7 publications

(9 citation statements)

References 8 publications

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“…6 Although most are single case reports, studies have shown that propranolol is also effective in the treatment of HH. 1,9,[23][24][25][26][27] In our study, complete response was obtained in 37.5% (6/16), and partial response was obtained in 56.5% (9/16) of the patients with medical treatment. Hemangioma dimensions remained stable in 3.2% (1/16) of the patients.…”

Section: Discussionsupporting

confidence: 49%

“…With the demonstration of its effectiveness in the treatment of cutaneous hemangiomas in 2008, a new era began in the treatment of hemangiomas,1,9,21,22 and propranolol was approved by the US Food and Drug Administration in 2014 6. Although most are single case reports, studies have shown that propranolol is also effective in the treatment of HH 1,9,23–27. In our study, complete response was obtained in 37.5% (6/16), and partial response was obtained in 56.5% (9/16) of the patients with medical treatment.…”

Section: Discussionmentioning

confidence: 50%

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A Retrospective Analysis of Clinical Characteristics, Treatment Modalities and Outcome of the Patients With Infantile Hepatic Hemangiomas: Single-Center Experience From Turkey

Al¹,

Demirağ²,

Erdem³

et al. 2022

Journal of Pediatric Hematology/Oncology

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Objective: Hepatic hemangiomas (HH) are the most common vascular tumors of the liver. It is important to distinguish hemangiomas from malignant liver tumors. Materials and Methods: The patients 0 to 1 years old, were diagnosed with HH and followed up in the oncology outpatient clinic between 2009 and 2020 were included in the study. Results: A total of 127 patients with the diagnosis of HH were included in the study. Of the patients, 99 (78%) had focal, 20 (15.7%) had multifocal, and 8 (6.3%) had diffuse HHs. Surgery was performed and the diagnosis was confirmed histopathologically in 6 patients (4.7%). During the follow-up, 16 (12.5%) patients received medical treatment. Thirteen (10.2%) were treated with propranolol, 2 (1.5%) with corticosteroids, and 1 (0.8%) with propranolol and corticosteroids. Complete response was obtained in 9 (9/16) patients and partial response was obtained in 6 (6/16) patients with medical treatment. Conclusion: Although HH is a benign tumor, it is important to make its differential diagnosis with malignant tumors of the liver. Over the years, the need for histopathologic examination for diagnosis has decreased. The success rate of propranolol is high, and the need for other treatment options with a high side-effect profile has decreased significantly since 2008.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 50%

A Retrospective Analysis of Clinical Characteristics, Treatment Modalities and Outcome of the Patients With Infantile Hepatic Hemangiomas: Single-Center Experience From Turkey

Al¹,

Demirağ²,

Erdem³

et al. 2022

Journal of Pediatric Hematology/Oncology

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“…No existen protocolos estandarizados internacionales, ni nacionales para el tratamiento de este tipo de tumor 8 . En la literatura se han comunicado series con muy pocos pacientes 3,9 . Las opciones terapéuticas de- penden de las características del tumor, si es solitario o multifocal, la presencia o ausencia de síntomas y la presencia o no de complicaciones [1][2][3]13 .…”

Section: Discussionunclassified

“…En un alto porcentaje de casos regresan en forma espontánea alrededor de los 12-18 meses de realizado el diagnóstico, sin necesidad de tratamiento 1,2 . De requerir, existen diferentes tratamientos médicos o intervencionistas dependiendo del tumor, entre ellos se destacan: uso de corticoides, propanolol, quimioterapia, embolización arterial, hepatectomía parcial y trasplante hepático [2][3][4][5][7][8][9] .…”

Section: Introductionunclassified

Hemangioendotelioma hepático infantil multifocal

2019

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Introducción: El hemangioendotelioma hepático (HEH) es un tumor benigno, raro en niños, que se presenta frecuentemente en el primer año de vida. La presentación clínica es variable y su diagnóstico se realiza en base a la sospecha clínica, estudios de laboratorio y de imagen. El objetivo fue describir un caso de hemangioendotelioma hepático multifocal.Caso clínico: Niña de 3 meses que presentó hepatomegalia sin elementos de falla hepática ni cardiaca. Se realizó ecografía y tomografía de abdomen que orientaron al diagnóstico de HEH que se confirmó con la angioresonancia de abdomen. Recibió glucocorticoides a altas dosis en forma prolongada. Al año y medio de iniciado el tratamiento se evidenció remisión del tumor. Presentó efectos secundarios por el tratamiento instaurado.Conclusiones: La presencia de una hepatomegalia aislada en un lactante asintomático debe hacer pensar en una probable patología tumoral, orientándonos por la clínica e imagenología al diagnóstico nosológico de la misma. Siempre se debe sospesar las posibles complicaciones con los riesgos de los tratamientos a realizar. En este caso la extensión del tumor y sus probables complicaciones justificó el uso de corticoterapia prologada a altas dosis a pesar de sus efectos adversos.

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“…4 Complications are rare, mainly due to compressive hepatomegaly and high-flow shunts and include pulmonary hypertension, congestive heart failure, and abdominal compartment syndrome. 1,[6][7][8] A remarkably interesting phenomenon is consumptive hypothyroidism. The pathophysiological mechanism is attributed to an enzyme, the type 3 iodothyronine deiodinase (D3).…”

Section: Introductionmentioning

confidence: 99%

Multifocal Infantile Hepatic Hemangiomas Complicated by Consumptive Hypothyroidism: The Benefits of Early Diagnosis and Treatment

Morais¹,

Alves

Coelho

et al. 2022

Journal of Pediatric Hematology/Oncology

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Infantile hepatic hemangiomas (IHH) account for 12% of all childhood hepatic tumors. Most IHH are diagnosed within the first 6 months of life and involute spontaneously; however, some require medical treatment. The present report describes a case of multifocal IHH associated with subcutaneous and lingual hemangiomas, complicated by consumptive hypothyroidism and successfully managed with oral propranolol and thyroid replacement therapy, without documented adverse effects. Consumptive hypothyroidism is a rare complication of IHH, but suggestive of multifocal/diffuse subtypes. The authors intend to reinforce the importance of early referral to a Vascular Anomalies Center and treatment with propranolol in selected patients.

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Infantile hepatic hemangioendothelioma successfully treated by low dose of propranolol

Cited by 7 publications

References 8 publications

A Retrospective Analysis of Clinical Characteristics, Treatment Modalities and Outcome of the Patients With Infantile Hepatic Hemangiomas: Single-Center Experience From Turkey

A Retrospective Analysis of Clinical Characteristics, Treatment Modalities and Outcome of the Patients With Infantile Hepatic Hemangiomas: Single-Center Experience From Turkey

Hemangioendotelioma hepático infantil multifocal

Multifocal Infantile Hepatic Hemangiomas Complicated by Consumptive Hypothyroidism: The Benefits of Early Diagnosis and Treatment

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