Infantile hemangioma: Predicting proliferation by infrared thermography

Strumila, Arūnas; Kazlauskas, Vytis; Pošiūnas, Gintas; Verkauskas, Gilvydas; Beiša, Virgilijus

doi:10.1016/j.medici.2017.04.002

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…Surface temperatures of IH at or above 37.4°C showed a sensitivity of 75% and a negative predictive value of 95%. 28 Medians of temperatures measured in stable IH, slightly growing IH and growing IH are 36.7°C, 37°C and 37.4°C, respectively. 28 Early treatment withdrawal and segmental IH are the potential causes of regrowth of IH.…”

Section: Discussionmentioning

confidence: 94%

“…28 Medians of temperatures measured in stable IH, slightly growing IH and growing IH are 36.7°C, 37°C and 37.4°C, respectively. 28 Early treatment withdrawal and segmental IH are the potential causes of regrowth of IH. 29 Balma-Mena et al 30 stated that the most significant predictor of regrowth after weaning was the size of IH over 5 cm.…”

Section: Discussionmentioning

confidence: 94%

“…To measure the surface temperature of IH by using an infrared thermometer helps to predict their proliferative potential. Surface temperatures of IH at or above 37.4°C showed a sensitivity of 75% and a negative predictive value of 95% . Medians of temperatures measured in stable IH, slightly growing IH and growing IH are 36.7°C, 37°C and 37.4°C, respectively .…”

Section: Discussionmentioning

confidence: 95%

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Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Kagami

Kaneko

Katori

2018

The Journal of Dermatology

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Infantile hemangiomas undergo rapid growth during early infancy followed by gradual involution. Infantile hemangiomas sometimes impair vital functions or cause disfigurement. Thirty-two Japanese patients between the ages of 1 and 4 months with proliferating infantile hemangiomas received oral propranolol on an outpatient basis. The success rate (complete or nearly complete resolution) at week 25 was 56% (18/32). Two patients dropped out because of a personal reason and moving out. Recurrence after termination of treatment was seen in six patients. Adverse events occurred in 16 patients. There were no adverse events on day 1 (initiation of treatment at a dose of 1 mg/kg per day) and day 8 (dose increase to 2 mg/kg per day). One patient was hospitalized due to pneumonia, and suspended propranolol for 26 days. Oral propranolol at 2 mg/kg per day is effective and safe in Japanese patients with infantile hemangiomas.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

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Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Kagami

Kaneko

Katori

2018

The Journal of Dermatology

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“…Using an infrared thermometer to measure the surface temperature of IH helps to predict their proliferative potential. Surface temperatures of IH at or above 37.4°C showed a sensitivity of 75% and a negative predictive value of 95% . Medians of temperatures measured in stable IH, slightly growing IH and growing IH are 36.7°C, 37°C and 37.4°C, respectively …”

Section: Discussionmentioning

confidence: 96%

Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment

Kagami

Kaneko

Kishi

et al. 2018

The Journal of Dermatology

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Infantile hemangiomas are the most common tumor of childhood and undergo rapid growth during early infancy followed by gradual involution. After involution, residual lesions sometimes remain. Oral propranolol usually induces earlier involution and redness reduction of infantile hemangiomas. However, the optimal treatment duration is unknown and infantile hemangiomas sometimes recur after cessation of treatment. We report three Japanese patients with recurrent infantile hemangiomas on their cheek. These patients were a 1-month-old female baby with a superficial infantile hemangioma, a 3-month-old female baby with a mixed infantile hemangioma and a 4-month-old male baby with a mixed infantile hemangioma. Two of them also received pulsed dye laser treatment. They did not reach complete or nearly complete resolution of infantile hemangiomas at week 25. These patients experienced regrowth of their infantile hemangioma after 20 months of age and took propranolol after the age of 24 months. There were no severe adverse effects. Propranolol may not only be therapeutic but also prophylactic. Patients with infantile hemangiomas who have taken oral propranolol should be followed up at least 6 months after cessation of treatment, especially infantile hemangiomas on the cheek, and those with partial response to propranolol may require close attention in prolonged growth.

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“…In this case, new interesting developments could be opened up for the gene therapy of breast cancer. Strumila et al [35] evaluated the activity of an infantile haemangioma using thermography, demonstrating that an increase in temperature corresponds to a phase of activity of haemangioma. It is therefore plausible that a thermographic study of CAs with respect to breast cancer could potentially clarify some aspects of pathogenesis and the time of appearance.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Breast Cancer on the Distribution of Cherry Angiomas on the Anterior Thoracic Wall: A Case Series Study

et al. 2018

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Background/Aims: Cherry angiomas (CAs) are one of the most common vascular manifestations of the skin. By and large, these benign lesions often only represent an aesthetic problem. In the literature, few authors have focused on the pathogenesis of these lesions, and some risk factors have been identified, such as the presence of cutaneous and non-skin neoplasias. In this study, the correlation between the distribution of CAs and breast cancer was investigated. Methods: We carried out a study whereby 50 women with unilateral breast cancer and the presence of CAs on the anterior thoracic wall were evaluated, with a particular focus on the difference in the number of CAs between the two haemithoraces. The data was elaborated using the Wilcoxon signed-rank test in order to evaluate whether there was a statistical significance in the distribution of CAs. Results: In 31 patients we found that the number of CAs was greater on the cancerous breast than on the contralateral one (p value <0.0001). This was confirmed both in the group of patients suffering from ductal breast cancer and in the group with early invasive breast tumours. Conclusion: It is not clear whether CAs develop prior to or following breast cancer, indicating the possibility that this cutaneous manifestation could take on a predictive, prognostic development or represent only an epiphenomenon. Further in-depth studies into the pathogenesis of CAs and the relationship with breast cancer could lead to noteworthy diagnostic-therapeutic advances.

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Infantile hemangioma: Predicting proliferation by infrared thermography

Abstract: IRT is a time and cost effective tool, and is easy to learn. The surface temperature of IH reflects its remaining growth potential and could be used in the outpatient setting for the evaluation and follow-up of IH.

Cited by 12 publications

References 26 publications

Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment

The Influence of Breast Cancer on the Distribution of Cherry Angiomas on the Anterior Thoracic Wall: A Case Series Study

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