Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment

Bandera, Ana Isabel Rodríguez; Sebaratnam, Deshan F; Wargon, Orli; Wong, Li‐Chuen

doi:10.1016/j.jaad.2021.08.019

Cited by 87 publications

(83 citation statements)

References 88 publications

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“…The most frequently affected organ is the liver, with a multifocal or diffuse pattern of IH. Although they follow the natural proliferation and involution course of IH and most are asymptomatic, a few might be associated with complications such as bleeding, high-output congestive heart failure, or hypothyroidism [7,8].…”

Section: Syndromes Associated With Ihmentioning

confidence: 99%

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

Kowalska

Dębek

Matuszczak

2021

JCM

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Infantile hemangiomas are the most common benign vascular tumors in infancy. This review includes an update on the current knowledge on pathogenesis, a discussion on indications for treatment, and a review of the mechanisms underlying the different treatment methods. Although most infantile hemangiomas require only active observation because of their natural course, which results in involution, about 10% present with complications that require immediate treatment. The basic treatment includes systemic and topical options. In cases of insufficient response or rebound growth, other forms of treatment should be considered. In some cases, combined therapy might be initiated.

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Section: Syndromes Associated With Ihmentioning

confidence: 99%

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

Kowalska

Dębek

Matuszczak

2021

JCM

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“…IHs are the most common pediatric vascular tumors, which start within the first few months of life, show a phase of endothelial cell proliferation that lasts on 6–18 months and slowly involutes 16 . Little is known about the pathogenesis of IHs, but local hypoxia is considered as a stimulus triggering vascular proliferation, which would represent a homeostatic response of the hypoxic tissue to the increased production of cytokines such as VEGF; however, this possibility is presently debated 17 .…”

Section: The First Step: From Ih To Ropmentioning

confidence: 99%

β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo

Filippi

Pini

Cammalleri

et al. 2021

Medicinal Research Reviews

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The role of the β-adrenoceptors (β-ARs) in hypoxia-driven diseases has gained visibility after the demonstration that propranolol promotes the regression of infantile hemangiomas and ameliorates the signs of retinopathy of prematurity (ROP). Besides the role of β2-ARs, preclinical studies in ROP have also revealed that β3-ARs are upregulated by hypoxia and that they are possibly involved in retinal angiogenesis. In a sort of figurative round trip, peculiarities typical of ROP, where hypoxia drives retinal neovascularization, have been then translated to cancer, a disease equally characterized by hypoxia-driven angiogenesis. In this step, investigating the role of β3-ARs has taken advantage of the assumption that cancer growth uses a set of strategies in common with embryo development. The possibility that hypoxic induction of β3-ARs may represent one of the mechanisms through which primarily embryo (and then cancer, as an astute imitator) adapts to grow in an otherwise hostile environment, has grown evidence. In both cancer and embryo, β3-ARs exert

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“…IH presents as a red, lobulated plaque in the superficial dermis or as a light blue mass subcutaneously ( 2 ). It has been reported that the incidence of IH ranges from 2-10% ( 3 ). Hypoxia and the renin-angiotensin system have been demonstrated as independent risk factors in the etiology of IH.…”

Section: Introductionmentioning

confidence: 99%

Real-time optical imaging of the hypoxic status in hemangioma endothelial cells during propranolol therapy

Xiao²,

Zhai³

et al. 2022

Front. Oncol.

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Infantile hemangioma (IH) is the most common microvascular tumor of infancy involving the area of head and neck. One of the most important independent risk factors of IH is the hypoxia microenvironment. Fluorescent chemosensor provides a noninvasive intervention, high spatiotemporal resolution, ultrasensitive response, and real-time feedback approach to reveal the hypoxic status of cells. Our research group developed an ultrasensitive fluorescent chemosensor, HNT-NTR, and investigated the potential ability of imaging the hypoxic status of hemangioma-derived endothelial cells (HemECs). In this study, we successfully visualized the propranolol (PRN) treatment in HemECs using NHT-NTR with “Turn-off” sensing method. This chemosensor exhibited high sensitivity and selectivity for optical imaging of hypoxic status with fast responsiveness, real-time feedback and durable photostability of the fluorescent signal. It was also confirmed that HNT-NTR could monitor nitroreductase in vivo. Paramountly, we expected this chemosensor to offer an available optical method for imaging of the hypoxic status and visualizing the therapeutic status of PRN therapy in IH with the hypoxia-imaging capability.

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Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment

Cited by 87 publications

References 88 publications

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo

Real-time optical imaging of the hypoxic status in hemangioma endothelial cells during propranolol therapy

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