Infantile hemangioma: a brief review

Bota, Mădălina; Popa, G; Blag, Cristina; Tătaru, Alexandru

doi:10.15386/cjmed-381

Cited by 13 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although benign neglect is the cornerstone for its treatment, sometimes the final results are unpredictable and incomplete, moreover the time period for complete involution is not definite. This time period may cause severe parents anxiety; therefore, intervention is required [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Five years’ experience of combined intralesional therapy in infantile hemangioma

Helal

Daboos

2019

Ann Pediatr Surg

View full text Add to dashboard Cite

Background: Infantile hemangiomas (IHs) are common vascular tumors. Although it involutes spontaneously, outcomes are unpredictable. Intralesional therapy is one of its treatment modality. We present our experience with combined intralesional therapy for IHs over a 5-year duration. A total of 427 patients were treated and followed at Al-Azhar University Hospitals during the study period of 5 years. All patients were treated by intralesional therapy in the form of combined injection of triamcinolone and bleomycin. All patients were followed for the response. Response to the treatment was graded as marked, partial, and poor improvement. Results: IHs were noticed within the first month of life in 90.2% of patients. The commonest site of involvement was head and neck in 90% of patients. The commonest clinical presentation was swelling with discoloration. Mean age was 7.43 ± 6.04 months and mean IHs size was 15.54 ± 11.13 cm 2. The response to the treatment was highest for patients below 1 year of age. The reported complications were ulceration, scarring, and subcutaneous atrophy in some cases. Conclusion: Combined intralesional therapy in IHs showed good efficacy in most patients. It is a reliable and safe treatment modality with clear curative effects and minimal complications. If IHs treatment is indicated, combined intralesional therapy should be considered as an alternative effective treatment modality.

show abstract

Section: Discussionmentioning

confidence: 99%

Five years’ experience of combined intralesional therapy in infantile hemangioma

Helal

Daboos

2019

Ann Pediatr Surg

View full text Add to dashboard Cite

show abstract

“…7 Both previous studies and physical manifestations have indicated the presence of hypoxic condition and its promotive role in IH. 8,9 However, the precise mechanism accounting for hypoxia-mediated IH progression has not been fully clarified. Therefore, it is essential to discover novel molecular events underlying this process, which may provide better insights into the biological course of IH.…”

Section: Research-article2017mentioning

confidence: 99%

Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma

Xia

Zhu

Wang

et al. 2017

J Histochem Cytochem.

View full text Add to dashboard Cite

SummaryAccumulating studies have revealed the hypoxic condition and its crucial role in the distinctive progression of infantile hemangioma (IH), the most common benign tumor in infancy. Activating transcription factor 4 (ATF4), an important gene mediating cellular adaptation to various stress signals, could confer a survival advantage for tumor cells under hypoxia and regulate tumor progression. However, the potential role of ATF4 in IH was still unknown. In this study, the expression of hypoxia inducible factor (HIF)-1α, ATF4, and macrophage colony-stimulating factor (M-CSF) in 27 specimens of IH was measured by immunochemistry and double-labeling immunofluorescence, followed by the Spearman rank correlation test. Our results showed that the expression of HIF-1α, ATF4, and M-CSF was significantly upregulated in proliferating IH compared with involuting IH. Meanwhile, HIF-1α and ATF4, in parallel with ATF4 and M-CSF, exhibited positive correlation and synchronous expression. In addition, our in vitro studies demonstrated that hypoxia obviously upregulated the expression of HIF-1α, ATF4, and M-CSF in hemangioma stem cells. Most importantly, their expression was uniformly correlated with the percentage of M2-polarized macrophages in IH. All those results and established evidence indicated that hypoxia-induced ATF4 expression may promote progression of proliferating IH through M-CSF-induced M2-polarized macrophages infiltration. (J Histochem Cytochem 65:285-294, 2017)

show abstract

“…Infantile hemangiomas (IH) are the most common benign tumor in infants and occur in 5-10 % of children [1]. According to the classification of the International Association for the Study of Vascular Anomalies (ISSVA) 2018, hemangiomas are benign vascular tumors and include IH, as well as congenital hemangiomas (rapid-involving, partially involute, non-involute) [2].…”

Section: Problem Descriptionmentioning

confidence: 99%

Particularities of the Course and Treatment Hemangiomas of Different Morphological Types in Children and Their Association With Soluble Forms of Fas and Fasl

Vivcharuk

2020

ScienceRise

View full text Add to dashboard Cite

The article discusses analysis of examinations and treatment results 100 children with hemangiomas different localizations on the different stages of existence. The study included patients of different ages, from birth to 6 years. Importance of primary assessment of severity and activity of hemangioma`s, for the choice of treatment, was considered. Correlation between clinical course of hemangiomas and soluble Fas/FasL was analyzed. The object of the research: Clinical course of hemangiomas of different morphological types, soluble form of Fas and FasL in the serum of patients with hemangiomas. Investigated problem: Improving the results of treatment of hemangiomas in children. The main scientific results: Predicting the course of hemangiomas in children allows to determine the need for treatment at different stages of their existence, as well as to carry out timely correction of the prescribed treatment to achieve good cosmetic and functional results. The area of practical use of the research results: Department of Pediatrics, Pediatric Surgery, Dermatology. Innovative technological product: Defined characteristics will help in predicting the course of hemangiomas and the effectiveness of their treatment. Scope of the innovative technological product: Clinical pediatric practice.

show abstract

Infantile hemangioma: a brief review

Cited by 13 publications

References 38 publications

Five years’ experience of combined intralesional therapy in infantile hemangioma

Five years’ experience of combined intralesional therapy in infantile hemangioma

Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma

Particularities of the Course and Treatment Hemangiomas of Different Morphological Types in Children and Their Association With Soluble Forms of Fas and Fasl

Contact Info

Product

Resources

About