Infantile Glaucoma in Down's Syndrome (Trisomy 21)

Traboulsi, Elias I.; Levine, Elliot M.; Mets, Marilyn B.; Parelhoff, Edward S.; O’Neill, John; Gaasterland, Douglas E.

doi:10.1016/0002-9394(88)90303-0

Cited by 25 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 There was a high prevalence of persistent epiphora in the population with Down syndrome (35%). In most children this resolved with conservative management (simple cleansing, massaging, and treatment of proven infection).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Surveillance of vision and ocular disorders in children with Down syndrome

Stephen

Dickson

Kindley

et al. 2007

Develop Med Child Neuro

View full text Add to dashboard Cite

Children with Down syndrome have a high prevalence of ocular disorders. The UK Down's Syndrome Medical Interest Group (DSMIG) guidelines for ophthalmic screening were locally implemented into a protocol that included neonatal eye examination by an opthalmologist and a comprehensive ophthalmological examination (cycloplegic refraction, ophthalmoscopy, and orthoptic assessement) by at least the age of 3 years, followed by preschool follow‐up as indicated. We audited retrospectively surveillance for ocular disorders before and after the DSMIG‐based guidelines were locally adopted in 1995. Results were compared for children born before and after the implementation of screening guidelines. A total of 81 children (43 females, 38 males) with Down syndrome were identified. After the DSMIG protocol, 34/36 children received a full ophthalmological examination in the neonatal period, compared with 9/27 children before 1995 (p<0.001). Neonatal screening resulted in the detection of cataracts in three infants. Mean age of first comprehensive ophthalmic screening outside the neonatal period was similar in the two groups (1y 6mo before guidelines vs 1y 9mo after), as were the proportion of children receiving preschool eye checks (27/30 before; 17/18 after). Overall, 65.7% children were screened in accordance with the guidelines, improving to 100% in recent years. At school age, 43% of the study population had significant refractive errors, with 27% having hypermetropia and astigmatism. Earlier prescription of glasses for refractive errors was seen (mean age 5y 6mo before guidelines; 3y 6mo after; p<0.001). Prevalence of other ocular disorders included strabismus (34/72, 47%), nasolacrimal duct obstruction (26/73, 35.6%), cataracts (5/64, 7.8%), and nystagmus (12/72, 16%). Establishment of the DSMIG‐based local protocol has streamlined ocular surveillance. It is anticipated that this will improve developmental and functional outcomes in Down syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6] An increased prevalence of conditions such as cataracts, infantile glaucoma, nystagmus, and keratoconus has also been reported. 6,7 Surveillance, leading to early recognition and correction, can be vital in preventing secondary disability for children with Down syndrome.…”

mentioning

confidence: 99%

Surveillance of vision and ocular disorders in children with Down syndrome

Stephen

Dickson

Kindley

et al. 2007

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…Infantile glaucoma is known to occur in Down's syndrome,[45] and the prevalence is reported to be between 6 and 12%;[67] however, glaucoma in Down's syndrome is usually bilateral and is postulated to be due to the high iris insertion. To our knowledge, this is the first reported case of bilateral ICE syndrome and glaucoma in a patient with Down's syndrome.…”

Section: Discussionmentioning

confidence: 99%

Bilateral iridocorneal endothelial syndrome in a young girl with Down′s syndrome

Gupta

Kumar

Gupta

et al. 2009

Indian J Ophthalmol

View full text Add to dashboard Cite

We describe the occurrence of bilateral iridocorneal endothelial (ICE) syndrome with glaucoma in a young girl with Down's syndrome. A 16-year-old girl with Down's syndrome was found to have secondary glaucoma in the right eye with features of progressive iris atrophy in both eyes. She was uncontrolled on maximum tolerable medical therapy for glaucoma. She underwent an uneventful trabeculectomy with mitomycin-C in her right eye. Scanning electron microscopy of the trabecular meshwork obtained in this case is described.

show abstract

“…19-38) are associated with congenital glaucoma in its isolated or syndrome forms, 9a,69 including trisomy 21 295 ; trisomy 13-15; trisomy 17-18 296,297 ; Turner's syndrome; trisomy 3q; chromosome 6 and its associations with both iridocorneodysgenesis and oculodentaldigital anomalies 252,298,299 ; and trisomy 2q. 300 Multiple ocular and systemic defects may be evident, with a large variation in their presentations.…”

Section: Chromosome Abnormalitiesmentioning

confidence: 98%

Developmental and childhood glaucoma

Stamper

2009

Becker-Shaffer's Diagnosis and Therapy of the Glaucomas

View full text Add to dashboard Cite

Infantile Glaucoma in Down's Syndrome (Trisomy 21)

Cited by 25 publications

References 25 publications

Surveillance of vision and ocular disorders in children with Down syndrome

Surveillance of vision and ocular disorders in children with Down syndrome

Bilateral iridocorneal endothelial syndrome in a young girl with Down′s syndrome

Developmental and childhood glaucoma

Contact Info

Product

Resources

About