Infantile Digital Fibromatosis/Inclusion Body Fibromatosis: A Comprehensive Literature Review

Abstract

Infantile digital fibromatosis (IDF), or inclusion body fibromatosis, is a rare benign tumor that commonly presents as a solitary nodule composed of spindle cells within the dermis on the digits of infants and children. Evaluation often includes a biopsy and typical therapies include observation, intralesional corticosteroid injections, and complete surgical resection. Given the rarity of IDF, few clinicians have direct or extensive experience diagnosing or treating it. Here we present a comprehensive review of the presentation, diagnosis, and treatment for IDF.

Inclusion Body Fibromatosis (Infantile Digital Fibromatosis) of the Shoulder in an Older Child: Answer

“…IBF is predominantly encountered in infants and young children with some reports in adults. 1,2 It was first described by Reye in 1965. The precise etiology of IBF remains unknown, although some cases have been reported presenting after previous trauma.…”

“…IBF is predominantly encountered in infants and young children with some reports in adults. 1,2 It was first described by Reye in 1965. The precise etiology of IBF remains unknown, although some cases have been reported presenting after previous trauma.Clinically, IBF presents as an asymptomatic, firm, fleshy, dome-shaped nodules, with most cases arising on the dorsal and lateral aspects of fingers and toes.…”

Borderline phyllodes tumour of the breast with eosinophilic inclusion bodies: Case report and molecular sequencing

“…IDF is a dermal fibroblastic and myofibroblastic lesion typically found as firm nodules on digits of infants and children. Intracytoplasmic inclusion bodies in stromal cells are a classic histopathologic finding and can be highlighted with special stains like Masson's trichrome [ 1 ]. However their presence in extradigital fibromatosis and in adults is rare.…”

“…Eosinophilic intracytoplasmic inclusion is a pathognomonic feature of infantile digital fibromatosis (IDF) [ 1 ]. It is a rare, superficial fibromatosis characterized by little, firm, painless, pink-red nodules on the fingers and toes of children.…”

Inclusion body fibromatosis

“…3 It is a rare and slow-growing tumor that usually affects infants and children (mostly in less than 5 years) with equal gender distribution. 4 These lesions most commonly affect the lateral and dorsal aspects of the last four digits, sparing the thumb, hand, or foot. Rarely, extremities, tongue, and breast act as the primary extradigital site.…”