Infantile cortical hyperostosis: Report of two cases

Prospect Hill: Skeletal Remains from a 19th-Century Methodist Cemetery, Newmarket, Ontario

“…The focus of lesions in the frontal and parietal regions of the skull bone is consistent with rickets, but the proliferative disorganized new bone growth and orbital involvement is inconsistent with the rickets pattern. The proliferation is consistent with infantile cortical hyperostosis, but in this condition the mandible is involved in 70-90% of all cases (Zachariades et al 1986), and the long bones frequently show prominent swelling. The extensive· cranial remodeling may be indicative of a hypercalcemic state, which is very serious in an infant.…”

Sporadic Congenital Infantile Cortical Hyperostosis (Caffey's Disease)

“…4 The diagnosis is usually made by exclusion. 10 The differential diagnosis of the congenital form includes osteogenesis imperfecta, camptomelic dysplasia, and hypophosphatasia. 4 Al- though our two cases are having the typical bone lesions of Caffey's disease, the absence of the characteristic translucency of the skeleton, fractures, and pencil thin cortex of long bones ruled out osteogenesis imperfecta.…”

“…No specific therapy is required to treat Caffey's disease. 10 However, in severe or relapsing cases steroids 1011 and naproxen 12 have been used with success. In our two cases we did not find a need to use any specific medication.…”

Infantile Generalized Pustular Psoriasis Associated With Lytic Lesions of the Bone

“…It is characterized by cortical hyperostosis, most often of the mandible or clavicle. Although other bones such as long bones, nasal bones and scapulae may be involved, the mandible is affected in 70% to 90% of cases (16). Areas overlying affected bone are usually swollen and painful.…”