“…Several factors have already been identified that may increase the risk of infantile colic. These include gastro-oesophageal reflux (Heine, 2006 ), increased levels of gastrointestinal hormones (Savino et al , 2006 ), flora (Savino et al , 2010 ), esophagitis (Berezin, Glassman, Bostwick & Halata, 1995), low birth weight (Søndergaard et al , 2000 ), maternal smoking (Reijneveld, Brugman & Hirasing, 2000 ), lactose intolerance (Kanabar, Randhawa & Clayton, 2001 ) and feeding difficulties (Gudmundsson, 2010 ; Miller-Loncar, Bigsby, High, Wallach & Lester, 2004 ). The etiology appears to be unknown (Kheir, 2012 ; Lucassen et al , 2001 ) and no standard treatment protocol for infantile colic has been indicated (Hall, Chesters & Robinson, 2012 ).…”