Infantile autism and Wernicke's encephalopathy

Simon, Nicole

doi:10.1016/0306-9877(90)90119-y

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…They are metabolically the most active structures in the brain, making them vulnerable to many injurious factors. If this control is lost it may result in the defects of awareness and responsiveness seen in autistic children [19]. Of parents of ASD children, 79% reported some concern regarding their feeding behavior compared to 64% of parents of typically developing children.…”

Section: The Potential Role Of Malnutrition In Autismmentioning

confidence: 99%

The Dilemma of Raised Blood Levels of Folate and B12 in Autism

Lonsdale¹

2018

J Neurodegener Disord

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It has recently been reported that a raised level of folate and/or vitamin B12 in the blood of a newly parturient woman forecasts a marked increase in the possibility that the newborn infant will later develop autisma. The text that follows refers to the cases of two boys, each of which had suffered repeated episodes of acute febrile cervical lymphadenopathy. The medical history of one of the boys revealed that he had been previously admitted to a hospital during an episode of febrile lymphadenopathy. An enlarged cervical node had been removed for biopsy and it had been reported that its architecture, apart from its enlargement, was normal. In addition, it had been found that blood levels of folate and vitamin B12 were markedly increased. His mother had been accused of giving him too many supplements of vitamins, including folate and vitamin B12. She stated that she had not been giving the boy any vitamin supplements at all, a fact that was met with disbelief. Both boys had been indulged with sweets and each were found to have laboratory evidence of thiamin deficiency or abnormal status. One of the boys was studied in detail and the elevation of folate and B12 in the blood was confirmed. He was treated with large doses of thiamin as an outpatient. On his return the blood folate and vitamin B12 were found to be in the normal range. Thiamin therapy was discontinued and three weeks later he had another episode of febrile lymphadenopathy which was preceded by nocturnal sleepwalking accompanied by spontaneous enuresis. Blood folate and B12 were again elevated and thiamin treatment was restarted. With overall improvement in health and no further episodes of febrile lymphadenopathy, the folate and B12 levels were again normal when he returned for follow-up.

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Section: The Potential Role Of Malnutrition In Autismmentioning

confidence: 99%

The Dilemma of Raised Blood Levels of Folate and B12 in Autism

Lonsdale¹

2018

J Neurodegener Disord

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“…Simon ( 63 ) suggested a metabolic similarity in WKS and autism. It was pointed out that thiamin deficiency, by disabling the aerobic pathway for glucose metabolism, is equivalent to oxygen deprivation.…”

Section: Dysautonomia In Autism and Sudden Infant Death Syndromementioning

confidence: 99%

Dysautonomia, a Heuristic Approach to a Revised Model for Etiology of Disease

Lonsdale

2007

Evidence-Based Complementary and Alternative Medicine

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Dysautonomia refers to a disease where the autonomic nervous system is dysfunctional. This may be a central control mechanism, as in genetically determined familial dysautonomia (Riley-Day Syndrome), or peripherally in the distribution of the sympathetic and parasympathetic systems. There are multiple reports of a number of different diseases associated with dysautonomia. The etiology of this association has never been explained. There are also multiple publications on dysautonomia associated with specific non-caloric nutritional deficiencies. Beriberi is the prototype of autonomic dysfunction. It is the best known nutritional deficiency disease caused by an imbalance between ingested calories and the vitamins required for their oxidation, particularly thiamin. Long thought to be abolished in modern medical thinking, there are occasional isolated reports of the full-blown disease in developed Western cultures.Apart from genetically and epigenetically determined disease, evidence is presented that marginal high calorie malnutrition, particularly with reference to simple carbohydrates, is responsible for widespread dysautonomia. The brain and heart are the organs that have a fast rate of oxidative metabolism and are affected early by any mechanism that reduces oxidative efficiency. It is hypothesized that this results in a chaotic state of the hypothalamic/autonomic/endocrine axis. Due to the lack of adequate automatic controls, this may be responsible in some cases for breakdown of organ systems through long-standing energy deficiency, thus leading eventually to organic disease.

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“…23 This type of hypoxic-ischemic injury is indeed common in the perinatal period and has been well recognized and studied. However, to my knowledge, no significant correlation has been established between such perinatal hypoxic injury and autism.…”

Section: Isabelle Rapin MD Bronx Nymentioning

confidence: 99%

Visual field constriction in children treated with vigabatrin

Wilkins¹

2000

Neurology

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Infantile autism and Wernicke's encephalopathy

Cited by 10 publications

References 32 publications

The Dilemma of Raised Blood Levels of Folate and B12 in Autism

The Dilemma of Raised Blood Levels of Folate and B12 in Autism

Dysautonomia, a Heuristic Approach to a Revised Model for Etiology of Disease

Visual field constriction in children treated with vigabatrin

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