1979
DOI: 10.1001/archderm.115.7.834
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Infantile acropustulosis

Abstract: Infantile acropustulosis is a syndrome that is characterized by recurrent crops of 1- to 2-mm, intensely pruritic vesicopustules on the distal extremities. The eruption is unresponsive to topical steroids, and pruritus is relieved only by soporific doses of antihistamines.

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Cited by 18 publications
(8 citation statements)
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“…In contrast with previously published cases [4][5][6], pustular content showed many eosinophils together with neutrophils. A possible explanation is that this is a typical case of IA occurring by chance in a baby with modest persistent eosinophilia and, since generally eosinophils migrate into exudates with an eosinophil/neutrophil ratio approximately similar to the ratio in blood, a mere contamination could be responsible for the occasional presence of eosinophils in the pustular content.…”
Section: Discussioncontrasting
confidence: 99%
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“…In contrast with previously published cases [4][5][6], pustular content showed many eosinophils together with neutrophils. A possible explanation is that this is a typical case of IA occurring by chance in a baby with modest persistent eosinophilia and, since generally eosinophils migrate into exudates with an eosinophil/neutrophil ratio approximately similar to the ratio in blood, a mere contamination could be responsible for the occasional presence of eosinophils in the pustular content.…”
Section: Discussioncontrasting
confidence: 99%
“…A possible explanation is that this is a typical case of IA occurring by chance in a baby with modest persistent eosinophilia and, since generally eosinophils migrate into exudates with an eosinophil/neutrophil ratio approximately similar to the ratio in blood, a mere contamination could be responsible for the occasional presence of eosinophils in the pustular content. Nevertheless, eosinophils are frequently found in infantile pustular erup tions; let us think, for example, of incontinentia pigmenti; and, as stressed by Jarratt andRam sdell [4], both erythema toxicum and transient pustular melanosis have eosinophils in their pustules. In our case, no cause for the persistent eosinophilia could be found and no other pathological condition except for IA was present.…”
Section: Discussionmentioning
confidence: 96%
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“…Infantile acropustulosis [2] is characterized by recurrent episodes of pruriginous pustules affecting the extremities (hands and feet), with a spontaneously favourable course over several months or years. Topical corticosteroids or dapsone are useful in severe forms associated with frequent or severe episodes [3]. Histological examination of the early lesions of acropustulosis [4] shows epidermal spongiosis, which subsequently leads to the formation of intra-epidermal vesicles and pustules, successively colonized by an infiltrate predominantly composed of neutrophils rather than eosinophils (fig.…”
Section: Discussionmentioning
confidence: 99%