Infant weight trajectories and early childhood wheezing: the NINFEA birth cohort study

Popović, Maja; Pizzi, Costanza; Rusconi, Franca; Galassi, Claudia; Gagliardi, Luigi; Marco, Laura De; Migliore, Enrica; Merletti, Franco; Richiardi, Lorenzo

doi:10.1136/thoraxjnl-2015-208208

Cited by 20 publications

(14 citation statements)

References 36 publications

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“…Those that used individual longitudinal childhood growth patterns observed that PWV was associated with a higher risk of asthma at 7 and 10 years of age,4 6 and that size and weight velocity (PWV) but not the time at which PWV occurred, were associated with a higher risk of wheezing at 18 months 10. Using the difference between two growth measurements instead, a study showed that a lower lung function partly explained the association of early weight gain and childhood asthma 22.…”

Section: Discussionmentioning

confidence: 99%

The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

Casas

Dekker

Kruithof

et al. 2018

Thorax

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Section: Discussionmentioning

confidence: 99%

The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

Casas

Dekker

Kruithof

et al. 2018

Thorax

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“…Moreover, maternal obesity may lead to metabolic and oxidative alterations in the placenta and the fetus 24 , and increased leptin level and insulin resistance in newborns 26 . Such pronounced changes may partly explain why excessive –or accelerated– weight gain in the first few months or years of life has also been linked to recurrent wheezing and incident asthma 27,28 .…”

Section: Maternal Obesity During Pregnancy and Weight Gain In Early Pmentioning

confidence: 99%

The effect of obesity, weight gain, and weight loss on asthma inception and control

Forno

Celedón

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of the review There is ample and growing evidence that obesity increases the risk of asthma and morbidity from asthma. Here we review recent clinical evidence supporting a causal link between obesity and asthma, and the mechanisms that may lead to “obese asthma”. Recent findings While in some children obesity and asthma simply co-occur, those with “obese asthma” have increased asthma severity, lower quality of life, and reduced medication response. Underlying mechanistic pathways may include anatomical changes of the airways such as obstruction and dysanapsis; systemic inflammation; production of adipokines; impaired glucose-insulin metabolism; altered nutrient levels; genetic and epigenetic changes; and alterations in the airway and/or gut microbiome. A few small studies have shown that weight loss interventions may lead to improvements in asthma outcomes, but thus far research on therapeutic interventions for these children has been limited. Summary Obesity increases the risk of asthma –and worsens asthma severity or control– via multiple mechanisms. “Obese asthma” is a complex, multifactorial phenotype in children. Obesity and its complications must be managed as part of the treatment of asthma in obese children.

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“…Accumulating evidence suggests an association between early growth patterns and wheezing in infancy. Within the NINFEA birth cohort, P opovic et al [9], using a novel modelling approach (SITAR) that allows for mutual adjustment of different aspects of growth, showed that larger size and faster growth over the first 18 months of life, but not the timing of peak weight velocity, were independently associated with an increased risk of wheezing at 18 months of age.…”

Section: Early Life Risk Factors For Wheezing and Asthmamentioning

confidence: 99%

Key paediatric messages from Amsterdam

Grigg

Barben²,

Bohlin

et al. 2016

ERJ Open Res

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The Paediatric Assembly of the European Respiratory Society (ERS) maintained its high profile at the 2015 ERS International Congress in Amsterdam. There were symposia on preschool wheeze, respiratory sounds and cystic fibrosis; an educational skills workshop on paediatric respiratory resuscitation; a hot topic session on risk factors and early origins of respiratory diseases; a meet the expert session on paediatric lung function test reference values; and the annual paediatric grand round. In this report the Chairs of the Paediatric Assembly's Groups highlight the key messages from the abstracts presented at the Congress.

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Infant weight trajectories and early childhood wheezing: the NINFEA birth cohort study

Abstract: Faster growth and larger size in the first 18 months of life are both independently associated with an increased risk of wheezing. These findings suggest that early growth patterns play a role in shaping the occurrence of wheezing.

Cited by 20 publications

References 36 publications

The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

The effect of obesity, weight gain, and weight loss on asthma inception and control

Key paediatric messages from Amsterdam

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