Infant lung function and early skin barrier impairment in the development of asthma at age 3 years
Martin Färdig,
Angela Hoyer,
Catarina Almqvist
et al.
Abstract:BackgroundLargely unexplored, we investigated if lower lung function, impaired skin barrier function by transepidermal water loss (TEWL), eczema, and filaggrin (FLG) mutations in infancy were associated with asthma in early childhood.MethodsFrom the factorially designed randomized controlled intervention study PreventADALL, we evaluated 1337/2394 children from all randomization groups with information on asthma at age 3 years, and at age 3 months either lung function, TEWL, eczema, and/or FLG mutations. Lower … Show more
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