Infant feeding and anti-tissue transglutaminase antibody concentrations in the Generation R Study

Jansen, Michelle A. E.; Tromp, Ilse; Jong, Jessica C. Kiefte-de; Jaddoe, Vincent W. V.; Hofman, Albert; Escher, Johanna C.; Hooijkaas, Herbert; Moll, Henriëtte A.

doi:10.3945/ajcn.114.090316

Cited by 37 publications

(48 citation statements)

References 32 publications

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“…However, it was unclear whether it provided long-term prevention against CD or only delayed the onset of the disease [24,[35][36][37] . Results of the recently published cohort studies did not confirm the protective effect of breastfeeding at the time of gluten introduction on developing CD [31,38] . Also, the pooled results for 7 observational studies showed that breastfeeding at the time of gluten introduction has no effect on the risk of developing CD compared with formula feeding (OR 0.88, 95% CI 0.52-1.51) [10] .…”

Section: Breastfeeding At the Time Of Gluten Introductionmentioning

confidence: 65%

“…A prospective Generation R cohort including 1,679 Dutch children positive for HLA-DQ2 and/or DQ8 evaluated the possible association of the timing of gluten introduction and breastfeeding duration with CD autoimmunity at 6 years of age. It was shown that breastfeeding for longer than 6 months was not related to a lower risk of CD autoimmunity [31] . Interestingly, the Norwegian Mother and Child Cohort Study (MoBa) involving more than 100,000 children showed that breastfeeding for longer than 12 months was associated with a higher risk of CD [32] .…”

Section: Exclusive or Any Breastfeeding And Duration Of Breastfeedingmentioning

confidence: 99%

“…Decker [25] No significant association between CD and BF duration Hummel [33] a /Ziegler [59] a , BABYDIAB No significant association between CD autoimmunity and BF duration Jansen [31], Generation R Study No significant association between CD autoimmunity and BF duration Norris [27], DAISY Study No significant association between CD autoimmunization and BF duration Roberts [28] No significant association between CD and BF duration Størdal [32], MoBa b…”

Section: Breastfeeding and CDmentioning

confidence: 99%

“…The Generation R Study found that later compared to earlier exposure was not significantly associated with CD autoimmunity [31] . The Norwegian Mother and Child Cohort Study (MoBa) showed that later but not earlier exposure to gluten increased the risk of CD, although this difference was of borderline significance (adjusted OR 1.27, 95% CI 1.01-1.65) [32] .…”

Section: Timing Of Gluten Introductionmentioning

confidence: 99%

“…Two new large cohort studies [31,32] reported data comparing the introduction of gluten before and after 6 months of age. The Generation R Study found that later compared to earlier exposure was not significantly associated with CD autoimmunity [31] .…”

Section: Timing Of Gluten Introductionmentioning

confidence: 99%

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Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition

et al. 2015

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Celiac disease (CD) is a common autoimmune disorder caused by ingestion of gluten. When diagnosed, it should be treated with a lifelong, strict gluten-free diet. Early infant feeding practices have been suggested as a means of preventing CD. In the last few decades, observational data have suggested that breastfeeding, especially at the time of introducing gluten into the infant's diet, as well as the time and mode of gluten first being given to a child could prevent or delay the occurrence of CD. As a result, recommendations advised that it is prudent to avoid both early (<4 months) and late (>7 months) introduction of gluten, and to introduce gluten gradually while the infant is still being breastfed, as this may reduce the risk of celiac disease, type 1 diabetes mellitus, and wheat allergy. Recently, the results of two large randomized trials have shown that breastfeeding in general, breastfeeding during gluten introduction, and early or delayed gluten introduction do not influence the total risk of CD in genetically predisposed individuals. Introducing gluten at 4 versus 6 months in very small amounts, or at 6 versus 12 months, resulted in similar rates of CD in these children. Thus, early feeding practices seem to have no impact on the risk of developing CD during childhood. In children without the genetic predisposition, the age and mode of gluten introduction do not influence the risk anyway.

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Section: Breastfeeding At the Time Of Gluten Introductionmentioning

confidence: 65%

Section: Exclusive or Any Breastfeeding And Duration Of Breastfeedingmentioning

confidence: 99%

Section: Breastfeeding and CDmentioning

confidence: 99%

Section: Timing Of Gluten Introductionmentioning

confidence: 99%

Section: Timing Of Gluten Introductionmentioning

confidence: 99%

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Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition

et al. 2015

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Environment‐Wide Association Study (EⁿWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population‐Based Study

et al. 2020

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A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data‐driven environmental‐wide association study of pre‐ and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6‐year‐old children from a birth cohort with pre‐ and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a test set (921). Multiple linear regression analyses were performed for each of 920 variables, correcting for six of the most common covariates in epidemiological studies. We found 111 different pre‐ and perinatal factors associated with autistic traits during childhood. In secondary analyses where we controlled for parental psychopathology, 23 variables in the domains of family and interpersonal relationships were associated with the development of autistic symptoms during childhood. In conclusion, a data‐driven approach was used to identify a number of pre‐ and perinatal risk factors associating with higher childhood autistic symptoms. These factors include measures of parental psychopathology and family and interpersonal relationships. These measures could potentially be used for the early identification of those at increased risk to develop ASD. Lay Summary A combination of genetic and environmental factors contributes to the development of autism spectrum disorder (ASD). Each environmental factor may affect the risk of ASD. In a study on 6‐year‐old children, a number of pre‐ and perinatal risk factors were identified that are associated with autistic symptoms in childhood. These factors include measures of parental psychopathology and family and interpersonal relationships. These variables could potentially serve as markers to identify those at increased risk to develop ASD or autistic symptoms. Autism Res 2020, 13: 1582–1600. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.

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Celiac Disease Prevention

Mearin

2021

Advances in Celiac Disease

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Celiac disease (CD) is a common autoimmune disorder induced by ingestion of gluten in genetically susceptible individuals. Despite the prerequisite for a genetic predisposition, only a minority of the 40% of the Caucasian population that has this genetic predisposition develops the disease. Thus, environmental and/or lifestyle factors play a causal role in the development of CD. The incidence of CD has increased over the last half-century, resulting in rising interest in identifying risk factors for CD to enable primary prevention. Early infant feeding practices have been suggested as one of the factors influencing the risk of CD in genetically susceptible individuals. However, recent large prospective studies have shown that neither the timing of gluten introduction nor the duration or maintenance of breastfeeding influence the risk of CD. Also, other environmental influences have been investigated as potential risk factors, but have not led to primary prevention strategies. Secondary prevention is possible through early diagnosis and treatment. Since CD is significantly underdiagnosed and a large proportion of CD patients are asymptomatic at the time of diagnosis, secondary prevention will not identify all CD patients, as long as mass screening has not been introduced. As following a gluten-free diet is a major challenge, tertiary prevention strategies are discussed as well.

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Infant feeding and anti-tissue transglutaminase antibody concentrations in the Generation R Study

Abstract: Delayed introduction of gluten beyond the age of 6 mo does not increase the risk of CDA. In addition, breastfeeding for ≥6 mo does not decrease the risk of CDA in children at 6 y of age.

Cited by 37 publications

References 32 publications

Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition

Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition

Environment‐Wide Association Study (EⁿWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population‐Based Study

Celiac Disease Prevention

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Infant feeding and anti-tissue transglutaminase antibody concentrations in the Generation R Study

Abstract: Delayed introduction of gluten beyond the age of 6 mo does not increase the risk of CDA. In addition, breastfeeding for ≥6 mo does not decrease the risk of CDA in children at 6 y of age.

Cited by 37 publications

References 32 publications

Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition

Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition

Environment‐Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population‐Based Study

Celiac Disease Prevention

Contact Info

Product

Resources

About

Environment‐Wide Association Study (EⁿWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population‐Based Study