Infant feeding and allergy.

Miskelly, F. G.; Burr, Michael Leslie; Vaughan-Williams, E.; Fehily, A. M.; Butland, B. K.; Merrett, T. G.

doi:10.1136/adc.63.4.388

Cited by 66 publications

(32 citation statements)

References 18 publications

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“…Whether breast-feeding prevents infants from developing food allergy is a largely debated matter [10,23,24,26], but the present study is not the proper tool to deal with this problem.…”

Section: Discussionmentioning

confidence: 99%

Food Allergy in Preterm Infants Fed Human Milk

Martino¹,

Donzelli

Galli³

et al. 1989

Neonatology

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In 80 preterms aged 9–24 months (mean age: 15.9) and in 80 sex- and age-matched full-terms the frequency of atopic diseases and of positive skin tests to 8 food and 6 inhalant allergens was determined. The two groups did not differ as to overall percentages of cutipositive subjects and patients with atopic diseases. In particular, frequencies of positive skin tests to foods and of atopic dermatitis (the peak prevalence of which occurs early in infancy) were similar in preterm (16.2 and 7.5%, respectively) and full-term (13.7 and 5.0%, respectively) infants. We suggest that preterm infants fed human milk are not at increased risk of developing food allergy and related diseases and that the absorption of antigens through the immature intestine does not seem to favor the development of an IgE sensitization to foods.

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“…Whether breast-feeding prevents infants from developing food allergy is a largely debated matter [10,23,24,26], but the present study is not the proper tool to deal with this problem.…”

Section: Discussionmentioning

confidence: 99%

Food Allergy in Preterm Infants Fed Human Milk

Martino¹,

Donzelli

Galli³

et al. 1989

Neonatology

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“…A cohort study was set up comprising infants with a family history of atopy. It incorporated a randomized trial of withholding cow's milk protein from half the participants during tbe first 4 montbs of life [11]; otber potential determinants were recorded prospectively. This paper presents the development of atopy and allergic disease up to the age of 7 years in this cohort; other findings have already been published [12].…”

Section: Introductionmentioning

confidence: 99%

The development of allergy in high-risk children

BURR¹,

MERRETT²,

DUNSTAN³

et al. 1997

Clin Exp Allergy

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“…Several previous prospective studies have shown a protective effect of feeding breast milk ( 1–9) or an extensively hydrolyzed casein – whey or soy formula ( 4–14) – on the incidence of atopic dermatitis and food allergy in high‐risk infants, when the period of the diet included at least the first 4–6 months of life and solid foods were not introduced until the age of 4 months ( 15). The different study designs, study populations, definitions, diagnostic criteria, and control for confounders (environmental factors) in the previous studies do not allow a comparison of the effect of different dietary regimens and hypoallergenic hydrolyzed formulas.…”

mentioning

confidence: 99%

Comparison of a partially hydrolyzed infant formula with two extensively hydrolyzed formulas for allergy prevention:A prospective, randomized study

Halken

Hansen

Jacobsen

et al. 2000

Pediatric Allergy Immunology

190

141

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The aim of this study was to compare the allergy-preventive effect of a partially hydrolyzed formula with two extensively hydrolyzed formulas, in infants with a high risk for development of allergic disease. High-risk infants from four Danish centres were included in the period from June 1994 to July 1995. Five-hundred and ninety-five high-risk infants were identified. High-risk infants were defined as having biparental atopy, or a single atopic first-degree relative combined with cord blood immunoglobulin E (IgE)> or =0.3 kU/l. At birth all infants were randomized to one of three different blinded formulas. All mothers had unrestricted diets during pregnancy and lactation and were encouraged to breast-feed exclusively. If breast-feeding was insufficient, one of the three formulas, according to randomization, was given during the first 4 months. It was recommended not to introduce cow's milk, cow's milk products. and solid foods until the age of 4 months. After the age of 4 months a normal unrestricted diet and conventional cow's milk-based formula were given when needed. All infants were followed-up prospectively with interview and physical examination at the age of 6, 12, and 18 months, and if any possible atopic symptoms were reported. If food allergy was suspected, controlled elimination/challenge procedures were performed in a hospital setting. Of 550 infants included in the study, 514 were seen at all visits and 36 were excluded owing to noncompliance. Of 478 infants who completed the study, 232 were exclusively breast-fed, 79 received an extensively hydrolyzed casein formula (Nutramigen), 82 an extensively hydrolyzed whey formula (Profylac), and 85 a partially hydrolyzed whey formula (Nan HA), during the first 4 months of life. These four groups were identical in regard to atopic predisposition, cord blood IgE, birthplace, and gender. Exclusively breast-fed children were exposed less to tobacco smoke and pets at home and belonged to higher social classes, whereas the three formula groups were identical concerning environmental factors. The frequency of breast-feeding was high; only eight (2%) children were not breast-fed at all. The three formula groups were identical in regard to duration of breast-feeding and age at introduction of formula and solid foods. No significant differences were found in the three groups of infants receiving formula milk regarding the cumulative incidence of atopic dermatitis or respiratory symptoms. The cumulative incidence of parental-reported cow's milk allergy was significantly higher in children fed partially hydrolyzed formula (Nan HA) compared with extensively hydrolyzed formula (Nutramigen or Profylac) at 12 and 18 months (NanHA, 7.1%; Nutramigen, 2.5%; Profylac, 0%; p=0.033). The cumulative incidence of confirmed cow's milk allergy was 1.3% (three of 232) in exclusively breast-fed infants, 0.6% (one of 161) in infants fed extensively hydrolyzed formula (Nutramigen or Profylac), and 4.7%(four of 85) in infants fed partially hydrolyzed formula (Nan HA). Partially hydrolyz...

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Infant feeding and allergy.

Cited by 66 publications

References 18 publications

Food Allergy in Preterm Infants Fed Human Milk

Food Allergy in Preterm Infants Fed Human Milk

The development of allergy in high-risk children

Comparison of a partially hydrolyzed infant formula with two extensively hydrolyzed formulas for allergy prevention:A prospective, randomized study

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