Infant exposure to fine particulate matter and traffic and risk of hospitalization for RSV bronchiolitis in a region with lower ambient air pollution

Abstract

Few studies investigate the impact of air pollution on the leading cause of infant morbidity, acute bronchiolitis. We investigated the influence of PM2.5 and other metrics of traffic-derived air pollution exposure using a matched case–control dataset derived from 1997 to 2003 birth and infant hospitalization records from the Puget Sound Region, Washington State. Mean daily PM2.5 exposure for 7, 30, 60 and lifetime days before case bronchiolitis hospitalization date were derived from community monitors. A regional land use regression model of NO2 was applied to characterize subject’s exposure in the month prior to case hospitalization and lifetime average before hospitalization. Subject’s residential proximity within 150 m of highways, major roadways, and truck routes was also assigned. We evaluated 2604 (83%) cases and 23,354 (85%) controls with information allowing adjustment for mother’s education, mother’s smoking during pregnancy, and infant race/ethnicity. Effect estimates derived from conditional logistic regression revealed very modest increased risk and were not statistically significant for any of the exposure metrics in fully adjusted models. Overall, risk estimates were stronger when restricted to bronchiolitis cases attributed to respiratory syncytial virus (RSV) versus unspecified and for longer exposure windows. The adjusted odds ratio (ORadj) and 95% confidence interval per 10 mcg/m3 increase in lifetime PM2.5 was 1.14, 0.88–1.46 for RSV bronchiolitis hospitalization. This risk was also elevated for infants who resided within 150 m of a highway (ORadj 1.17, 0.95–1.44). This study supports a developing hypothesis that there may be a modest increased risk of bronchiolitis attributable to chronic traffic-derived particulate matter exposure particularly for infants born just before or during peak RSV season. Future studies are needed that can investigate threshold effects and capture larger variability in spatial contrasts among populations of infants.

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

“…Several studies have found an association between PM 2.5 and infant bronchiolitis, an important risk for hospitalization (Karr et al, 2007(Karr et al, , 2009a. Exposure to PM 2.5 has also been linked to low lung function in 4-year-old children in a birth cohort study in the Netherlands (Eenhuizen et al, 2012), supporting previously published studies that reported effects of PM 2.5 on lung function development, reviewed in Götschi et al (2008).…”

The effect of ego-motion on environmental monitoring

“…However, these models are more suitable for long-term, chronic exposure studies, due to their aggregative nature, and the possible loss of short-term localized measurements needed for more acute exposure incidents (Karr et al, 2009;Brauer, 2010). A better solution may be to use a denser array of sensing nodes, and thus create a better interpolation, closer to the real-life pollution dispersion scenario (Kanaroglou et al, 2005).…”

Infant swimming in chlorinated pools and the risks of bronchiolitis, asthma and allergy

“…The risk of bronchiolitis is also higher for infants living with older siblings, attending a day-care centre or exposed to environmental tobacco smoke [2,7]. Since ambient air pollution appears to play, if any, a marginal role [8], factors driving the rise of the disease in industrialised countries remain largely unknown.…”