Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study

Haapanen, Markus J; Perälä, Mia-Maria; Osmond, Clive; Salonen, Minna K.; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; Bonsdorff, Mikaela von

doi:10.1007/s40520-018-1011-0

Cited by 8 publications

(16 citation statements)

References 20 publications

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“…Among men, those included in the “increasing BMI cluster” were particularly at risk of frailty. Increased risk of frailty in weight‐gain groups was also found in other studies . Selection bias, where the most robust individuals with obesity still participate in the study in 2015, could contribute to the observed difference in frailty risk between the weight gain group and the consistently high BMI group.…”

Section: Discussionsupporting

confidence: 76%

“…The results indicated that, compared with the reference trajectory (consistently overweight), all other trajectories were associated with an increased risk of frailty, especially in the case of weight gain. Recently, Haapanen et al determined that greater BMI gain in early childhood was associated with an increased risk of frailty in late life among the men of the Helsinki Birth Cohort Study .…”

Section: Introductionmentioning

confidence: 99%

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Association Between Life‐Course Obesity and Frailty in Older Adults: Findings in the GAZEL Cohort

Landré

Czernichow

Goldberg

et al. 2020

Obesity

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► Frailty is a predictor of poor health outcomes among older adults. ► Although weight loss is part of frailty, previous studies demonstrated that aged individuals with obesity are more likely to be frail compared with aged individuals without obesity. ► The impact of life-course obesity on the risk of frailty in old age remains poorly described.What does this study add?► In a cohort of older adults followed for 26 years, we showed that the duration of obesity influences the risk of frailty: the longer the period of obesity, the higher the risk of frailty. ► We also identified a persisting effect of obesity on the risk of frailty among individuals who previously had obesity.Objective: This study aimed to assess the relationship between weight history during adulthood and frailty in late life in men and women participating in the GAZEL (GAZ and ELectricité) cohort.Methods: This cohort study included 8,751 men and 3,033 women (aged 61 to 76 years) followed up since 1989. Modified Fried's frailty criteria (weakness, fatigue, unintentional weight loss, low physical activity, and impaired mobility) were assessed in 2015. Reported BMI was determined each year to characterize: obesity status in 2015, obesity duration over the 1990 to 2015 period, and trajectories of BMI. Associations between frailty and weight history were assessed using multinomial regression.Results: In 2015, 12% of men had obesity, 1.8% severe obesity, and 0.4% morbid obesity; for women, these percentages were 11%, 2.2%, and 0.8%, respectively. Individuals with obesity were more likely to be frail than those with normal BMI and the risk of frailty increased with each additional year of obesity (adjusted odds ratio 1.04 [1.00-1.08] for men and 1.07 [1.02-1.13] for women). Trajectories of BMI revealed that both long-term obesity and onset of obesity in late adulthood were associated with frailty.Conclusions: Current and past obesity appear to be important determinants of frailty. Early weight management may be beneficial in old age.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Association Between Life‐Course Obesity and Frailty in Older Adults: Findings in the GAZEL Cohort

Landré

Czernichow

Goldberg

et al. 2020

Obesity

View full text Add to dashboard Cite

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“…On the negative side of the spectrum, postnatal growth velocity indicators showed a negative association with HGS, a result that is consistent with the high incidence of postnatal malnutrition due to diarrhoeal diseases and the late introduction of foods that are different from the mother´s milk, a pattern commonly found in Tlaltizapán [11,12]. In the same way, in a Finnish cohort study, BMI increases from ages 2 to 11 years in males (but not in females) was positively associated with frailty at 67-79 years of age [44]. In contrast, in a British cohort, height increases, from ages 2 to 7 years, was also related to HGS but with a positive effect [42].…”

Section: Discussionsupporting

confidence: 73%

Physical capability in a rural birth cohort at the age of 52: association with early environmental, nutritional, and developmental factors

et al. 2022

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Introduction Midlife physical capability (PC) is associated with developmental factors in the populations of economically developed countries. As far as we know, there is no information for rural populations of low- and middle-income countries. The aim of the study was to investigate the influence of pre- and postnatal factors on midlife objective measures of PC in a 1966–67 birth cohort from a Mexican rural community. The hypothesis was that adverse developmental conditions are associated with low midlife PC. Methods In 1966–67, a birth cohort of all children from a poor Mexican rural community was assembled. Data on family socioeconomic status (SES), parental health and nutritional status, birth weight, postnatal growth and feeding patterns were registered. In 2018, out of the 336 cohort members, 118 were living in the community, and eighty-two of them underwent a comprehensive clinical evaluation. The evaluation included grip strength, gait velocity and chair-stand PC tests. In multivariable linear models, PC tests were the dependent variables, and prenatal, birth and postnatal factors were the independent variables. Adjustment for confounding was made with adult anthropometric, body composition, clinical and ageing status variables. Results Independent of adult health status and other ageing indicators, lower PC was associated with family organization and SES, parental nutritional status, birth weight, infant postnatal growth velocity, and weaning time. These results indicate that adverse family and environmental conditions that are prevalent in poor rural communities are associated with low midlife PC.

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“…Deficit accumulation leading to increased frailty occurs across the human life course. Early life influences are reflected in birth cohort studies 147,148 and cross-sectional population studies from ages 20 and younger 149,150 . Country-of-origin studies [151][152][153] also reveal important effects.…”

Section: Frailty and Age-related Deficit Accumulationmentioning

confidence: 99%

The degree of frailty as a translational measure of health in aging

2021

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Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study

Abstract: Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.

Cited by 8 publications

References 20 publications

Association Between Life‐Course Obesity and Frailty in Older Adults: Findings in the GAZEL Cohort

Association Between Life‐Course Obesity and Frailty in Older Adults: Findings in the GAZEL Cohort

Physical capability in a rural birth cohort at the age of 52: association with early environmental, nutritional, and developmental factors

The degree of frailty as a translational measure of health in aging

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