Infancy Onset of Symptoms of Narcolepsy in a Child

Witmans, Manisha; Kirk, Valerie

doi:10.1177/000992280204100809

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Excessive sleepiness might be interpreted as a physiological need of napping in a small child, and in turn as a manifestation of laziness in older children. In addition to the excessive sleepiness, memory lapses, concentration problems and automatic behaviors, especially during monotonous activities, are also associated and can result in learning disabilities at school age [1,2,5,12,13] . Repeated difficulty in achieving expected or desired levels of performance might lead to irritability, hyperactivity, aggressiveness or even depression [2] .…”

Section: Introductionmentioning

confidence: 99%

Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital

Costa¹,

Barreto²,

Clemente

et al. 2014

Sleep Science

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Narcolepsy, a chronic disorder of the sleep–wake cycle of multifactorial etiology, is characterized by excessive daytime sleepiness, often associated with cataplexy, hypnagogic/hypnopompic hallucinations and sleep paralysis. Both early clinical suspicion and therapeutic approach are essential for promotion of cognitive development and social integration of these children. The authors present a descriptive retrospective study of a series of eight children in whom symptoms first started between 6.8 and 10.5 years of age. Diagnostic delay ranged from 4 months to 2 years. One child had H1N1 flu vaccination eight months before the clinical onset. The first multiple sleep latency test was positive in 6 of 8 cases. All cases were treated with methylphenidate, and venlafaxine was associated in 4 of them. In one case the initial therapy was exclusively behavioral. In all cases, symptomatic improvement, better school performance and social integration were achieved after therapeutic adjustment.

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Section: Introductionmentioning

confidence: 99%

Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital

Costa¹,

Barreto²,

Clemente

et al. 2014

Sleep Science

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“…Napping behaviors may simply mask daytime sleepiness in the very young and it has been suggested that the persistence of daytime napping after about 4 years of age may be an early indicator of childhood EDS (23). The transition to school, which precludes compensatory napping, often leads to the identification of this daytime sleepiness, as a 'problem behavior' (4,6,10). In the previous review of prepubertal narcolepsy 78% of children over 5 presented with daytime sleepiness in response to school based concerns of abnormal sleepiness and associated attentional difficulties (22).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…She described a specific episode when the patient was playing and laughing with her grandmother when she collapsed to the floor abruptly, without provocation and then fell asleep soon afterward (p. 609, Ref. 6).…”

Section: Cataplexymentioning

confidence: 99%

“…The literature has traditionally classified narcolepsy as a disorder of adulthood with childhood cases being described as atypical. However, several factors, including (i) a genetic component to the etiology of the illness (2), (ii) the retrospective reporting of many adult sufferers of childhood onset of symptoms (3), and, (iii) a growing case study evidence base of childhood incidents of the disorder (4)(5)(6)(7)(8)(9)(10)(11)(12)(13), would support the contention that the disorder should be more widely acknowledged as an illness of childhood and adolescence. More recent neurobiological research implicating the degeneration of orexin neurons in the pathogenesis of narcolepsy is also consistent with the potential for childhood illness onset.…”

Section: Introductionmentioning

confidence: 99%

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Narcolepsy: diagnosis and management in early childhood

Hood

Harbord

2015

J Pediatr Neurol

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This paper provides an overview of the diagnosis and management of narcolepsy in early childhood. Focusing on the case literature for children aged eight years and under the paper reviews aspects of the pathophysiology, clinical symptomology and clinical management of the illness. In addition factors critical to the differential diagnosis of narcolepsy from a range of other pediatric illnesses are discussed. The literature examining the psychosocial implications of the disorder for children is also presented. Two major themes emerge from this review (i) the need for a reconceptualisation of the current diagnostic criteria for narcolepsy to allow for the observed heterogeneity and developmental variability of childhood onset narcolepsy, and, (ii) the need for increased attention to the psychosocial difficulties experienced by children in adjusting to this chronic illness. (J Pediatr Neurol 2004; 2(2): 65?71).

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Narcolepsy in childhood

Nevšímalová¹

2009

Sleep Medicine Reviews

110

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Infancy Onset of Symptoms of Narcolepsy in a Child

Cited by 4 publications

References 9 publications

Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital

Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital

Narcolepsy: diagnosis and management in early childhood

Narcolepsy in childhood

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