Inertial flow focusing: a case study in optimizing cellular trajectory through a microfluidic MEMS device for timing-critical applications

Patterson, Luke; Walker, Jennifer L.; Naivar, Mark A.; Rodriguez-Mesa, Evelyn; Hoonejani, Mehran R.; Shields, Kevin; Foster, John S.; Doyle, Adele M.; Valentine, Megan T.; Foster, Kimberly L.

doi:10.1007/s10544-020-00508-1

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Since the aforementioned analytical solutions are unobtainable, suitable numerical procedures have to be selected, and it becomes imperative to evidence the pros and cons of each method [ 25 , 26 , 30 , 31 , 32 ]. MEMS is a rampant technology employed for realizing thermo-elastic systems [ 1 , 33 , 34 , 35 , 36 , 37 ], and it has a wide variety of applications ranging from biomedical engineering to microfluidics [ 38 , 39 , 40 , 41 , 42 ]. Moreover, many researchers are actively engaged in the development of important experimental research works for the development and prototyping of special MEMS such as, for example, circular graphene membrane MEMS devices [ 43 , 44 ], SiN circular membrane MEMS devices [ 45 , 46 ], and CMOS MEMS-based membrane-bridge devices [ 47 ] particularly useful for industrial applications.…”

Section: Introductionmentioning

confidence: 99%

A Semi-Linear Elliptic Model for a Circular Membrane MEMS Device Considering the Effect of the Fringing Field

Versaci

Jannelli

Morabito

et al. 2021

Sensors

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In this study, an accurate analytic semi-linear elliptic differential model for a circular membrane MEMS device, which considers the effect of the fringing field on the membrane curvature recovering, is presented. A novel algebraic condition, related to the membrane electromechanical properties, able to govern the uniqueness of the solution, is also demonstrated. Numerical results for the membrane profile, obtained by using the Shooting techniques, the Keller–Box scheme, and the III/IV Stage Lobatto IIIa formulas, have been carried out, and their performances have been compared. The convergence conditions, and the possible presence of ghost solutions, have been evaluated and discussed. Finally, a practical criterion for choosing the membrane material as a function of the MEMS specific application is presented.

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Section: Introductionmentioning

confidence: 99%

A Semi-Linear Elliptic Model for a Circular Membrane MEMS Device Considering the Effect of the Fringing Field

Versaci

Jannelli

Morabito

et al. 2021

Sensors

View full text Add to dashboard Cite

show abstract

P188 Therapy in In Vitro Models of Traumatic Brain Injury

Zargari

Meyer

Riess

et al. 2023

IJMS

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Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Varied mechanisms of injury contribute to the heterogeneity of this patient population as demonstrated by the multiple published grading scales and diverse required criteria leading to diagnoses from mild to severe. TBI pathophysiology is classically separated into a primary injury that is characterized by local tissue destruction as a result of the initial blow, followed by a secondary phase of injury constituted by a score of incompletely understood cellular processes including reperfusion injury, disruption to the blood-brain barrier, excitotoxicity, and metabolic dysregulation. There are currently no effective pharmacological treatments in the wide-spread use for TBI, in large part due to challenges associated with the development of clinically representative in vitro and in vivo models. Poloxamer 188 (P188), a Food and Drug Administration-approved amphiphilic triblock copolymer embeds itself into the plasma membrane of damaged cells. P188 has been shown to have neuroprotective properties on various cell types. The objective of this review is to provide a summary of the current literature on in vitro models of TBI treated with P188.

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Inertial flow focusing: a case study in optimizing cellular trajectory through a microfluidic MEMS device for timing-critical applications

Cited by 2 publications

References 33 publications

A Semi-Linear Elliptic Model for a Circular Membrane MEMS Device Considering the Effect of the Fringing Field

A Semi-Linear Elliptic Model for a Circular Membrane MEMS Device Considering the Effect of the Fringing Field

P188 Therapy in In Vitro Models of Traumatic Brain Injury

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