INEL BNCT research program, July--August 1992

Abstract

1 _j This report presents summaries for two months of current research of the Idaho National ._ Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and taurine screening experiments of low-density lipoprotein, carboranyl _ alanine, and liposome boron containing compounds. Pituitary tumor c_ll culture studies are : described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and : boronophenylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.