Inefficacy of topical methoxalen plus UVA for palmoplantar pustulosis

Abstract

The effect of local application of 8-methoxypsoralen (8-MOP) and subsequent UVA irradiation on palmoplantar pustulosis (PPP) was studied in 10 patients. In 8 patients 8-MOP baths were used, and in 5 patients an 8-MOP ointment was applied, 3 patients receiving both forms of treatment. The number of treatment sessions varied from 15 to 128, with maximal UVA doses of 1.2 to 12 J/cm2, and total cumulative doses of 8 to 348 J/cm2. Two patients experienced a brisk phototoxic erythema and one patient developed a bullous reaction. Only 3 patients responded favourably to the treatment, 2 with moderate and 1 with good clearing of the lesions. In the remaining 7 patients either no effect (5 patients) or an exacerbation of the disease (2 patients) was seen.

Palmoplantar Pustulosis: A Systematic Review of Risk Factors and Therapies

“… 32 , 33 Partial or complete response and good or excellent improvement occurred in 46.7% and 10–80% of patients, respectively. 34–36 Another clinical trial showed better response on the palms compared to the soles (complete clearance occurred in 31/36 palms but only in 5/34 soles). 37 …”

“…32,33 Partial or complete response and good or excellent improvement occurred in 46.7% and 10-80% of patients, respectively. [34][35][36] Another clinical trial showed better response on the palms compared to the soles (complete clearance occurred in 31/36 palms but only in 5/34 soles). 37 UVA1 has shown good efficacy for PPP with PPASI 75 occurring in 72.6% of patients 38 and significant superiority to UVB, 39 but it was significantly inferior to PUVA.…”