Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG

Prantera, Cosimo; Scribano, Maria Lia; Falasco, Giuliano; Andreoli, A.; Luzi, C

doi:10.1136/gut.51.3.405

Cited by 502 publications

(289 citation statements)

References 33 publications

Supporting

Mentioning

276

Contrasting

Unclassified

Order By: Relevance

“…No significant differences in clinical or endoscopic recurrence rates were found between patients receiving LGG or placebo to maintain surgical remission (Prantera et al 2002). Similarly, Schultz et al (2004) have shown no significant effect of LGG in maintaining remission induced with antibiotics and steroids.…”

Section: Probiotics and Prebiotics To Maintain Remission In Crohn's Dmentioning

confidence: 90%

Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials

2007

View full text Add to dashboard Cite

Human subjects and their enteric microbiota have evolved together to reach a state of mutual tolerance. Mounting evidence from both animal models and human studies suggests that inflammatory bowel disease (IBD) represents a malfunction of this relationship. The enteric microecology therefore represents an attractive therapeutic target with few side effects. Probiotics and prebiotics have been investigated in clinical trials as treatments for IBD, with conflicting results. The evidence for the use of probiotics in the management of pouchitis is persuasive and several studies indicate their effectiveness in ulcerative colitis. Trials of probiotics and prebiotics in Crohn's disease are less convincing. However, methodologies vary widely and a range of probiotic, prebiotic and combination (synbiotic) treatments have been tested in a variety of patient groups with an assortment of end points. Conclusions about any one treatment in a specific patient group can therefore only be drawn on evidence from relatively small numbers of patients. The present article reviews the role of the intestinal microbiota in the pathogenesis of IBD and addresses the clinical evidence for the therapeutic manipulation of bowel microbiota using probiotics, prebiotics and synbiotics in IBD.

show abstract

Section: Probiotics and Prebiotics To Maintain Remission In Crohn's Dmentioning

confidence: 90%

Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials

2007

View full text Add to dashboard Cite

show abstract

“…Inflammatory Bowel Disease (IBD) is a chronic and recurrent inflammation generally affecting the colon or the small intestine and includes ulcerative colitis [84] and Crohn's disease [85]. The aetiology of IBD remains unclear although there is evidence that the immune system reacts abnormally towards the endogenous microflora.…”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

“…Antibiotics associated diarrhea Lactobacillus GG [119] Enterococcus [76] Saccharomyces boulardii [79] Clostridium difficile associated diarrhea Saccharomyces bouladii [83] Bacteriodes spp [84] Inflammatory bowel disease S. salivarius subsp [89] Bifidobacterium infantis [85] Irritable bowel syndrome Bifidobacterium infantis [85] Colon cancer Bifidobacterium Clostridium perfringers [102] Urinary tract infection Lactobacillus GR-1 [111] Lactobacillus B-54…”

Section: Diseasementioning

confidence: 99%

Omnipresence of Probiotics in Diversified Clinical Practices

Singh¹

2015

J Prob Health

View full text Add to dashboard Cite

As reviewed in details about the bidirectional relationship between the positive influence of probiotics and wellness of humans. Beneficial effects of probiotics in the present scenario are recently developed very popular due to its therapeutics responsible for human health in different diseased conditions. Despite the globally popularity of health benefits of probiotics, there is only very little information available on the advantages and application of probiotics. According to the National Centre for Complementary and Alternative Medicine in connection with the American Society for Microbiology and FAO/WHO focused on account beneficial effects of probiotics in different diseased conditions of patients because of its unconstrained power in the treatment of various diseases and disorders especially gastro intestinal and cancer diseases. On the basis of accumulating data available on literature have strongly linked with human health. Hence, the present review reflected on an overview on the use of probiotics organisms as live supplements, with specific importance on Lactobacillus acidophilus and Bifidobacterium spp. Increasing knowledge on probiotics is delighting, but in the near future it must be specified that which probiotics are most effective in specific diseases conditions. Well-designed, randomized clinical trials are still required to further define the role of probiotics as preventive and therapeutic agents. The purpose of this review is to give current state of awareness about probiotics and their influence on our well-being.

show abstract

“…Three studies using LGG have not confirmed the effectiveness of this probiotic as a maintenance strategy after surgically-induced remission [84,85]. Another clinical trial utilizing treatment with LGG after surgical resection failed to show prevention of early endoscopic recurrence when compared to placebo.…”

Section: Probiotics To Maintain Remission In CDmentioning

confidence: 99%