Ineffectiveness of 5-Fluorouracil and Cis-Platin as Second-Line Chemotherapy in Head and Neck Cancer

Merlano, Marco; Conte, Pier Franco; R, Tatarek; Scarsi, Pietro; Barbieri, A.; Benedetti, G.; Rosso, Riccardo

doi:10.1177/030089168407000312

Cited by 8 publications

(1 citation statement)

References 5 publications

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“…The total search revealed 6366 articles on WPWS. The search yielded 24 cohorts with a preoperative or perioperative diagnosis of the WPWS in association with procedures of the head and neck/oral and maxillofacial region and have been summarized in Table 1 8–31 …”

Section: Resultsmentioning

confidence: 99%

Wolff–Parkinson–White syndrome: Review of published cases associated with head and neck/oral and maxillofacial procedures

et al. 2022

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Aim The objective of this article is to review the demographics, diagnostic criteria, etiopathogenesis, comorbidities and management of Wolff–Parkinson–White syndrome (WPWS). In addition, the relevant cardiovascular outcomes of published cases involving head and neck/oral and maxillofacial procedures were summarized. Materials and Methods A search of the PubMed database, restricted to human studies published in the English language literature, was performed from 1960 through July 2021 for articles. Results The search strategy yielded 24 patients, totalling 25 dates of treatment, with WPWS concordant with head and neck/oral and maxillofacial procedures, predominately involving biopsy, tumour resection and extractions; significantly, 5 of whom, experienced their first episode of WPWS while undergoing treatment of the head and neck. None of the procedures resulted in patient death. Conclusions Practitioners should be familiar with the clinical features of WPWS and be prepared to manage emergent cardiovascular deterioration. Electrocardiogram monitoring of this cohort is advised during head and neck/oral and maxillofacial surgical procedures, particularly involving general anaesthesia. Breakthrough episodes of WPWS may still occur in patients who have previously undergone cardioconversion.

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Section: Resultsmentioning

confidence: 99%

Wolff–Parkinson–White syndrome: Review of published cases associated with head and neck/oral and maxillofacial procedures

et al. 2022

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Clinical trials with fluorinated pyrimidines in patients with head and neck cancer

Al‐Sarraf

1989

Invest New Drugs

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While it is estimated to be one of the most prevalent cancers in the world, cancer of the head and neck is an uncommon malignant tumor in the United States and accounts for only 5% of all malignancies. Head and neck cancer is a term that encompasses heterogeneous groups of patients. The most common histologic type is the squamous cell carcinoma. Cancer of the oral cavity is the most common site among the head and neck tumors. The majority of patients (70-80%) present with locally advanced (Stage III and IV) cancer. The standard treatments of surgery and/or radiotherapy have a high cure rate for patients with early disease (Stages I or II), but not for patients with locally advanced tumors. Local recurrence and persistent disease occur in more than 60% of patients present with advanced cancer, and approximately 10%-20% of all patients develop distant metastases. Chemotherapy is usually used for palliation in patients with recurrent and metastatic head and neck cancer at which time these patients have failed the definitive therapy of surgery and/or radiotherapy and the chances for salvage is almost nil. With the identification of more active cytotoxic agent(s) and combinations, chemotherapy is being investigated as part of multi-modality treatment in patients with previously untreated and locally advanced head and neck cancer.

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Carboplatin and 5-fluorouracil in advanced and recurrent squamous carcinoma of the head and neck

1993

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Ineffectiveness of 5-Fluorouracil and Cis-Platin as Second-Line Chemotherapy in Head and Neck Cancer

Cited by 8 publications

References 5 publications

Wolff–Parkinson–White syndrome: Review of published cases associated with head and neck/oral and maxillofacial procedures

Wolff–Parkinson–White syndrome: Review of published cases associated with head and neck/oral and maxillofacial procedures

Clinical trials with fluorinated pyrimidines in patients with head and neck cancer

Carboplatin and 5-fluorouracil in advanced and recurrent squamous carcinoma of the head and neck

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