Industrial use of pepper (Capsicum annum L.) derived products: Technological benefits and biological advantages

Baenas, Nieves; Belović, Miona; Ilić, Nebojša; Moreno, Diego A.; García‐Viguera, Cristina

doi:10.1016/j.foodchem.2018.09.047

Cited by 244 publications

(137 citation statements)

References 95 publications

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“…It was suggested that capsaicin can open tight junctions via a unique and reversible dual-action mechanism. Firstly, capsaicin caused an influx of Ca 2+ into the cells, which led to cofilin dephosphorylation that directly induced depolymerization of F-actin leading to the opening of tight junctions [1,16]. Secondly, the total concentration of occludin expression was reduced, while a redistribution of actin at the bicellular tight junctions was seen [17,19].…”

Section: Resultsmentioning

confidence: 99%

“…Caco-2 (human colon adenocarcinoma) and KB-C2 (human papillomavirus-related endocervical adenocarcinoma) cell lines [4]. In addition, it was proven that capsaicin presents with analgesic, antimicrobial, and antioxidant effects [1,3]. Black pepper (Piper nigrum L.) and long pepper (Piper longum L.) belong to the genus Piper for which piperine (▶ Fig.…”

Section: Introductionmentioning

confidence: 99%

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Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

et al. 2019

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The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals isolated from different pepper species have been found to modulate the pharmacokinetics of orally administered drugs. This study investigated the possibility to apply capsaicin and piperine (extracted alkaloids) as modulators for drug delivery across the nasal epithelium. Both a nasal epithelial cell line (RPMI 2650) and excised sheep nasal tissue were used as models to investigate the effects of the selected pepper compounds on drug permeation. FITC-dextran 4400 (MW 4400 Da) was used as a large molecular weight marker compound for paracellular transport, while rhodamine 123 was used as a marker compound that is a substrate for P-glycoprotein-mediated efflux. From the permeation results, it was clear that capsaicin inhibited P-glycoprotein efflux to a larger extent, while piperine showed drug permeation enhancement via other mechanisms. The cell cytotoxicity studies indicated that capsaicin was noncytotoxic up to a concentration of 200 µM and piperine up to a concentration of 500 µM as indicated by cell viability above 80%. The histological analysis of the excised nasal tissue and cultured RPMI 2650 cell layers indicated that some damage occurred after treatment with 200 µM capsaicin, but no changes were observed for piperine up to a concentration of 50 µM.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

et al. 2019

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“…The top 10 pepper producing countries produced 30.7 and 3.85 million tons of green and dry pepper, respectively, in 2017, and production has dramatically increased over the past decades (Food and Agriculture Organization of the United Nations). The wide variability and genetic diversity of peppers allows the development of new varieties for use in the industry and market [1]. Recently, the genome sequence of C. annum provided more advanced associations between genomic studies and important traits [2,3].…”

Section: Introductionmentioning

confidence: 99%

A comparison of the nutrient composition and statistical profile in red pepper fruits (Capsicums annuum L.) based on genetic and environmental factors

et al. 2019

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Red peppers are a remarkable source of nutrients in the human diet. However, comprehensive studies have not reported on the effects of genotype, cultivation region, and year on pepper fruit characteristics. To address this, 12 commercial pepper varieties were grown at two locations in South Korea, during 2016 and 2017, representing four environments, and concentrations of proximate, minerals, amino acids, fatty acids, capsaicinoids, and free sugars in pepper pericarps were determined. Variation in most nutrients was observed among the 12 varieties grown within each location in each year, indicating a significant genotype effect. Statistical analysis of combined data showed significant differences among varieties, locations, and years for the measured components. The % variability analysis demonstrated that environment (location and year) and genotype-environment interaction contributed more to the nutritional contents than genotype alone. Particularly, variation in many amino acids, capsaicinoids, free sugars, and myristic acid was attributed to location. Year effect was significant for palmitoleic acid, ash, tryptophan, copper, linolenic acid, crude fiber, and tyrosine. Insoluble dietary fiber, soluble dietary fiber, sodium, sulfate, linoleic acid, and alanine were primarily varied by genotype–environment interaction. Palmitic acid was the trait the most highly affected by genotype. Cultivation and the genotype–environment interaction have a major role in determining the composition of 12 pepper varieties across four environments. The data from this study could explain the natural variation in the compositional data of peppers by genotypes and environments.

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“…37 The economic importance of peppers is mainly related to the chemical profile of the fruits, providing flavors, odors and biological properties largely explored in the manufacture of cosmetics, nutritional supplements, food additives and as an ingredient in different meals recipes. 38,39 The pungency of Capsicum is attributed to the presence of a chemical class produced exclusively by the species of this botanical genus, the capsaicinoids (CAPS). 40 This chemical class comprises a set of alkaloids with molecular structure consisting of a vanillic group, an amide and a carbon chain, which is responsible for the formation of different types of capsaicinoids ( Figure 3).…”

Section: The Genus Capsicummentioning

confidence: 99%

Perspectives and Applications of Natural Products as Civilian Defense Devices

Antonio¹,

Fonseca²,

Mendes³

et al. 2019

J. Braz. Chem. Soc.

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Civilian defense devices are physical and chemical artefacts used to incapacitate an aggressor without causing death or injury. As city violence increases, safety feelings became worst and a growing commercial demand for these materials supply faces technologically challenges not only to riot control but also to self-protection. Controversies on the use of these devices have been discussed, especially on their toxicity when synthetic chemical agents are used. Natural metabolites are a less explored alternative to meet this demand. They have the capacity to generate a temporary disabling effect due to their pungency. Those metabolites, which include capsaicinoids, gingerols and piperine, can be used as deterrent agents in civilian defense devices due to their low toxicity to humans. Although they are a viable alternative, there are few studies focused on their quality control, efficiency and toxicity. This review aimed to present relevant aspects about the development and use of natural products as deterrent agents in self-defense devices against aggressors and animals, and as non-lethal weapons for riot control in order to help the scientific development of this type of bioproduct. was a member of the CAPES and Brazilian pharmacopoeia committees and has published 143 articles in specialized magazines, 13 patents and 38 book chapters, with 50 thesis and dissertations supervised.

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Industrial use of pepper (Capsicum annum L.) derived products: Technological benefits and biological advantages

Cited by 244 publications

References 95 publications

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

A comparison of the nutrient composition and statistical profile in red pepper fruits (Capsicums annuum L.) based on genetic and environmental factors

Perspectives and Applications of Natural Products as Civilian Defense Devices

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