Industrial hemp-based dietary supplements and cosmetic products

Bakowska-Barczak, Anna; Esparza, Yussef; Kaur, Harmandeep; Popek, Tomasz

doi:10.1016/b978-0-323-90910-5.00010-5

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…Research suggests that CSO has a balanced ratio of ω-3 and ω-6 fatty acids, which are crucial for reducing inflammation and promoting tissue regeneration ( Smith, 2000 ; Komarnytsky et al, 2021 ; Ben Necib et al, 2022 ). Additionally, the oil is rich in antioxidants such as vitamin E, known for their skin-repairing properties ( Raiciu et al, 2016 ; Kotnala et al, 2019 ; Bakowska-Barczak et al, 2022 ). These characteristics are believed to improve skin elasticity and reduce scarring during the healing process.…”

Section: Resultsmentioning

confidence: 99%

In vivo and in silico studies of the effects of oil extracted from Cannabis sativa L. seeds on healing of burned skin wounds in rats

Bouarfa,

Chebaibi,

Ez-Zahra Amrati

et al. 2024

Front. Chem.

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IntroductionThis study investigates the potential effects of cannabis seed oil (CSO) on the wound healing process. The aim was to assess the efficacy of CSO in treating skin wounds using an animal model and to explore its anti-inflammatory properties through in silico analysis.MethodsEighteen male albino Wistar rats, weighing between 200 and 250 g, were divided into three groups: an untreated negative control group, a group treated with the reference drug silver sulfadiazine (SSD) (0.01 g/mL), and a group treated topically with CSO (0.962 g/mL). The initial wound diameter for all groups was 1 cm. In silico studies were conducted using Maestro 11.5 to evaluate the anti-inflammatory effects of phytoconstituents against cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).ResultsCSO and SSD treatments led to a significant reduction (p <0.05) in the size of burned skin wounds by day 5, with contraction rates of 53.95% and 45.94%, respectively, compared to the untreated negative control group. By day 15, wounds treated with CSO and SSD had nearly healed, showing contraction rates of 98.8% and 98.15%, respectively. By day 20, the wounds treated with CSO had fully healed (100%), while those treated with SSD had almost completely healed, with a contraction rate of 98.97%. Histological examination revealed granulated tissue, neo-blood vessels, fibroblasts, and collagen fibers in wounds treated with CSO. In silico studies identified arachidic acid, γ-linolenic acid, and linolenic acid as potent inhibitors of COX-1 and COX-2. Serum biochemical parameters indicated no significant changes (p > 0.05) in liver and kidney function in rats treated with CSO, whereas a significant increase (p < 0.01) in ALAT level was observed in rats treated with SSD.DiscussionThe findings demonstrate that CSO has a promising effect on wound healing. The CSO treatment resulted in significant wound contraction and histological improvements, with no adverse effects on liver and kidney function.However, the study's limitations, including the small sample size and the need for detailed elucidation of CSO's mechanism of action, suggest that further research is necessary. Future studies should focus on exploring the molecular pathways and signaling processes involved in CSO’s pharmacological effects.

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Section: Resultsmentioning

confidence: 99%

In vivo and in silico studies of the effects of oil extracted from Cannabis sativa L. seeds on healing of burned skin wounds in rats

Bouarfa,

Chebaibi,

Ez-Zahra Amrati

et al. 2024

Front. Chem.

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Role of Cannabis sativa L. in the Cosmetic Industry

Sarkar¹,

Sadhukhan

2023

Cannabis Sativa Cultivation, Production, and Applications in Pharmaceuticals and Cosmetics

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Cannabis sativa L. is a flowering plant in the family Cannabaceae, and has been cultivated since ancient times for its fibres, oils, resins, dried inflorescences, and leaves. It can be used for a variety of industrial purposes. Over the years, the therapeutic and pharmacological efficacy of its phytoconstituents is shown in a variety of human diseases and health. The use and exploitation of the plant have sparked controversy; however, there are recent legalizations of its use for medical and other purposes in many countries within the corresponding legislative framework. In addition to this legalization, C. sativa is encouraging the very rapid growth of the cannabis oriented pharmaceutical industry. This chapter summarized recent developments in the science of C. sativa and its products about their industrial application, while also addressing gaps in the existing knowledge and future research directions for this high-value multi-use, and potential industrial plant with universal benefits.

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Industrial hemp-based dietary supplements and cosmetic products

Cited by 2 publications

References 89 publications

In vivo and in silico studies of the effects of oil extracted from Cannabis sativa L. seeds on healing of burned skin wounds in rats

In vivo and in silico studies of the effects of oil extracted from Cannabis sativa L. seeds on healing of burned skin wounds in rats

Role of Cannabis sativa L. in the Cosmetic Industry

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