Industrial biotechnology for the production of bio-based chemicals – a cradle-to-grave perspective

Hatti‐Kaul, Rajni; Törnvall, Ulrika; Gustafsson, Linda; Börjesson, Pål

doi:10.1016/j.tibtech.2007.01.001

Cited by 276 publications

(140 citation statements)

References 42 publications

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“…Utilizing natural resources will place limitations on manufacturing, but will also achieve environmental sustainability and will constitute non-solid waste safe for environmental discharge, in the form off particle, nutrient free and sterile effluents [13]. Therefore the utilization of waste as a valuable commodity and platform chemicals ''mine'' is an important step for the development and deployment of alternative sources of energy production [14].…”

Section: Introductionmentioning

confidence: 99%

Grape Winery Waste as Feedstock for Bioconversions: Applying the Biorefinery Concept

Zacharof

2016

Waste Biomass Valor

140

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Grape wine is among the most important alcoholic beverages in the globe, with a continuously rising world demand, currently sizing at 25 billion litres. Such a large and heavily industrialised market calls for the maintenance of a steady production of raw materials to end products. Consequently, intensive cultivation of land, harvesting of the goods and manufacturing for the production of commercially available products are being implemented. Wine making is a timed, multistage process producing a large amount of organic and inorganic waste. It has been calculated that during cultivation and harvesting about 5 tonnes of solid waste are generated per hectare per year, while the winery wastewater varies according to the production size from 650,000 m 3 (Greece) to over 18,000,000 m 3 (Spain) per year. Conventional treatments of winery waste are becoming increasingly expensive, demanding significant amounts of effort, resources and energy for safe waste discharge. Therefore, the need to recycle, reuse and recover energy and valuable chemicals from winery waste and wastewater becomes apparent. Valorisation of winery waste is possible when introducing the concept of biorefinery, i.e. the use of winery waste as bioconversions feedstock in order to produce platform chemicals, biofuels, heat and energy.

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Section: Introductionmentioning

confidence: 99%

Grape Winery Waste as Feedstock for Bioconversions: Applying the Biorefinery Concept

Zacharof

2016

Waste Biomass Valor

140

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“…Biocatalysts commonly outperform chemical catalysts with respect to regio-and substrate selectivity and are active under mild, sustainable and aqueous reaction conditions (Arends et al 2007 ;Hatti-Kaul et al 2007 ;Hollmann et al 2011 ;Rozzel 1999 ). Today, enzymatic and whole-cell catalysis has found a broad range of applications, particularly in the production of fine chemicals, pharmaceuticals or agricultural intermediates (Meyer 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Production of halophilic proteins using Haloferax volcanii H1895 in a stirred-tank bioreactor

Strillinger

Grötzinger

Allers

et al. 2015

Appl Microbiol Biotechnol

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The success of biotechnological processes is based on the availability of efficient and highly specific biocatalysts, which can satisfy industrial demands. Extreme and remote environments like the deep brine pools of the Red Sea represent highly interesting habitats for the discovery of novel halophilic and thermophilic enzymes. Haloferax volcanii constitutes a suitable expression system for halophilic enzymes obtained from such brine pools. We developed a batch process for the cultivation of H. volcanii H1895 in controlled stirred-tank bioreactors utilising knockouts of components of the flagella assembly system. The standard medium Hv-YPC was supplemented to reach a higher cell density. Without protein expression, cell dry weight reaches 10 g L . Two halophilic alcohol dehydrogenases were expressed under the control of the tryptophanase promoter p.tna with 16.8 and 3.2 mg g , respectively, at a maximum cell dry weight of 6.5 g L . Protein expression was induced by the addition of L-tryptophan. Investigation of various expression strategies leads to an optimised two-step induction protocol introducing 6 mM L-tryptophan at an OD of 0.4 followed by incubation for 16 h and a second induction step with 3 mM L-tryptophan followed by a final incubation time of 4 h. Compared with the uncontrolled shaker-flask cultivations used until date, dry cell mass concentrations were improved by a factor of more than 5 and cell-specific enzyme activities showed an up to 28-fold increased yield of the heterologous proteins.

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“…A better understanding of the CaCO 3 dissolution in acidifying microbiological processes can increase the practical applications of CaCO 3 as neutralizing agent in biotechnological processes such as anaerobic fermentations where bio-based chemicals such as lactic acid and acetic acid are produced (Hatti-Kaul et al, 2007) or in wastewater treatment plants (the anaerobic digestion process). This can substantially reduce the operational costs since CaCO 3 has 60-80 % lower price (Halmann & Steinfeld, 2006) compared to the commonly applied alkaline materials in anaerobic systems which are soda ash (Na 2 CO 3 ), caustic soda (NaOH), and hydrated lime (Ca(OH) 2 ) (Isenburg & Moore, 1992;Metcalf et al, 2002).…”

Section: Practical Application Of Caco 3 In Biotechnological Processesmentioning

confidence: 99%

“…The commercial application of CaCO 3 as a neutralizing compound is however limited because of difficulties in controlling the pH due to presumed slow kinetics of CaCO 3 dissolution and instability of the pH (Maree & Duplessis, 1994;Watten et al, 2007). Commercial application of CaCO 3 as neutralizing agent can be of great interest in the context of production of bio-based products (material, chemical and energy) where the cost efficiency of the process justifies their ultimate feasibility (Hatti-Kaul et al, 2007). Reducing the cost of each step can contribute to the development of the bioproduct (van Wyk, 2001).…”

Section: Introductionmentioning

confidence: 99%

Mineral CO2 sequestration by environmental biotechnological processes

Salek

Kleerebezem

Jonkers

et al. 2013

Trends in Biotechnology

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Industrial biotechnology for the production of bio-based chemicals – a cradle-to-grave perspective

Cited by 276 publications

References 42 publications

Grape Winery Waste as Feedstock for Bioconversions: Applying the Biorefinery Concept

Grape Winery Waste as Feedstock for Bioconversions: Applying the Biorefinery Concept

Production of halophilic proteins using Haloferax volcanii H1895 in a stirred-tank bioreactor

Mineral CO2 sequestration by environmental biotechnological processes

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