Induktion von Fieber und Fiebertoleranz durch inkomplette Influenzaviren

Grossgebauer, K; Schmidt, Bernhard; Schmidt, G.; Langmaack, H

doi:10.1007/bf02123752

Z. med. Mikrobiol. u. Immunol.

1967

DOI: 10.1007/bf02123752

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Induktion von Fieber und Fiebertoleranz durch inkomplette Influenzaviren

K Grossgebauer

Bernhard Schmidt

G. Schmidt

et al.

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1967

1969

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Cited by 2 publications

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“…nieity is bound to a morphologically intact virus particle. It was found that both complete and incomplete viruses are pyrogenie (14). The component in the virus envelope which evokes the fever is biochemieMly probably a lipoprotein (34,35).…”

mentioning

confidence: 99%

Enhancement and neutralization of pyrogenicity of influenza viruses by various biologically active substances

Grossgebauer

Langmaack

Schmidt

et al. 1969

Archiv f Virusforschung

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The pyrogenicity of bacteria, bacterial products, fungi and viruses is usually tested in rabbit pyrogen test. The current hypothesis on the pathogenesis of fever is as follows (1, 13, 36): First, granulocytes and mononuclear cells phagocytize the virus particles, that is the exogeneous pyrogen, and then release an (lysosomal ?) endogeneous pyrogen. This substance is identical with the ]eukocytic pyrogen and seems to act directly on the hypothalamus. Besides the endogeneous pyrogen just mentioned other biologically active compounds are also to be found in the serum (e.g. lysozym% interferon and other antibacterial or antiviral substances). After a single injection of a large quantity of virus particles complete tolerance is induced in test animals. A second inoculation of exogeneous pyrogen leads no longer to a pyrogenic reaction. An identical or similar mechanism is assumed for the action of bacterial endotoxin.The complete mechanism of pathogencsis of microbially-induced fever is poorly understood. One way of studying this problem is to investigate single steps in the development of fever. It is possible to influence a) the exogeneous pyrogen itself (e.g. by heat, chemicals or specific antibodies (32, 36) ; b) the conditions of phagocytosis (e.g. by adding cations, anions or enzymes or by varying the osmosis (1, 31) ; II*

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mentioning

confidence: 99%

Enhancement and neutralization of pyrogenicity of influenza viruses by various biologically active substances

Grossgebauer

Langmaack

Schmidt

et al. 1969

Archiv f Virusforschung

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show abstract

Virusbedingtes Fieber

Grossgebauer

1967

Klin Wochenschr

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Induktion von Fieber und Fiebertoleranz durch inkomplette Influenzaviren

Cited by 2 publications

References 15 publications

Enhancement and neutralization of pyrogenicity of influenza viruses by various biologically active substances

Enhancement and neutralization of pyrogenicity of influenza viruses by various biologically active substances

Virusbedingtes Fieber

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