Inductively coupled plasma mass spectrometry for metallodrug development: Albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes

Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes

“…The values of log P equalled 0.41 for complex 4 and –0.07 for complex 6 indicating that the prepared complexes are markedly more hydrophobic than cisplatin with log P = –2.19 [38]. …”

Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents

“…Some oxime organic derivatives have been reported to have biological effects such as endothelium-independent relaxation in blood-vessels, an increase in the targeting of specific nuclear bases of DNA and oxidative DNA cleavage [42,43]. Oxime-containing Pt(II) compounds have been reported as a novel class of nonclassic platinum-based complexes with interesting antitumor properties, different DNA binding behaviour and a different pattern of protein interaction from those found in classical cisplatin [44,45]. The study on a variety of Rh(III) and Ir(III) compounds with oximato ligands show a strong cytotoxic effect toward HeLa and HL60 cancer lines, whereas the compounds do not modify DNA in a similar way to that of cisplatin [46].…”

Hydrogen Bonding and Anticancer Properties of Water‐Soluble Chiral p‐Cymene RuII Compounds with Amino‐Oxime Ligands

“…Oxime-containing Pt(II) compounds have been recently reported as a novel class of nonclassic platinum-based complexes with interesting antitumor properties, different DNA binding behavior and a different pattern of protein interaction from those found in classical cisplatin. [27,28] A variety of Rh(III) and Ir(III) compounds with oximate ligands have also been studied. [29] The results show a strong cytotoxic effect toward HeLa and HL60 cancer lines, whereas the compounds do not modify DNA in a similar way to that of cisplatin.…”