Abstract:We have developed five mouse monoclonal antiidiotypic antibodies to the 35/56 (Ab1) rat monoclonal that neutralizes retroviral infectivity by binding to the gp70f epitope of murine leukemia retrovirus. The anti-Id nature of these five Ab2s was evidenced by their inability to react with a panel of six other rat IgG2a kappa monoclonals isotype-matched to the 35/56 anti-gp70f mAb1, including two to the distinct epitopes "g" and "h" of gp70, or to normal rat IgG2a. On the basis of several competition assays four m… Show more
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