Induction time for resistance to microsporidial gill disease caused by Loma salmonae following vaccination of rainbow trout (Oncorhynchus mykiss) with a spore-based vaccine

Ultrastructural examination of the host inflammatory response within gills of netpen reared chinook salmon (Oncorhynchus tshawytscha) with Microsporidial Gill Disease

“…However, it may also partially be explained by species differences. Whereas work by Rodriguez-Tovar et al [8] demonstrates that the onset of resistance in rainbow trout occurred at three weeks (PE) and was complete by six weeks (PE), we have yet to define the onset time for chinook salmon. If substantially delayed, this could explain our findings.…”

Effects of dexamethasone on host innate and adaptive immune responses and parasite development in rainbow trout Oncorhynchus mykiss infected with Loma salmonae

“…After clearance of the parasite, strong resistance to reinfection with the parasite has been shown for both rainbow trout and Chinook salmon [9,10]. Using a vaccine preparation it has been shown that onset of resistance in rainbow trout occurs at about 3 weeks post exposure and at 6 weeks post exposure there is complete resistance [11]. Similarly to many other intracellular pathogens the resistance is attributed to cellular immunity rather than humoral immunity [11,12].…”

Fish microsporidia: Immune response, immunomodulation and vaccination

“…Early attempts to find a vaccine showed promising results when rainbow trout was inoculated with a live low-virulence variant of L. salmonae (SV strain), which demonstrated a substantial lowering of the intensity of the parasite infection [96]. It has been demonstrated that by using an inactivated spore-based spore vaccine, the beginning of resistance in rainbow trout occurs approximately 3 weeks after exposure and 3 weeks later there is a complete resistance, as observed by a reduction in the xenoma intensity [97]. The best protection was observed when fish received a dose between 10 3 and 10 5 of frozen spores of the L. salmonae SV strain intraperitoneally.…”