1995
DOI: 10.1117/12.209125
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Induction or prevention of intimal hyperplasia by photodynamic therapy in a porcine model

Abstract: Photodynamic therapy (PDT) has been proposed as a treatment for intimal hyperplasia (ll{). We studied the effect of PDT on the development of ill following endothelial injury, using the photosensitizer Metatetrahydroxyphenyl-chiorin (mTHPC) and 652 nm illumination. 9 minipigs were used in 3 groups of 3 . Pigs in the first group (balloon alone; BA) were anaesthetised and the lower 4 cm of abdominal aorta was denuded using a balloon catheter through the right femoral artery. In the second group (light alone, LA)… Show more

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“…One paradox that relates to other vascular PDT studies where several investigators could not achieve inhibition of IH with PDT, is in fact that PDT appeared to accelerate the development of stenotic lesions (13)(14)(15)). In the present study, it is hypothesized that conflicting data with reference to the ability of PDT to inhibit M in injured arteries may be based not only on the use of divergent protocols, animal models and vessel sizes, but on the different photosensitizer and light dosimetry employed.…”
Section: Introductionmentioning
confidence: 99%
“…One paradox that relates to other vascular PDT studies where several investigators could not achieve inhibition of IH with PDT, is in fact that PDT appeared to accelerate the development of stenotic lesions (13)(14)(15)). In the present study, it is hypothesized that conflicting data with reference to the ability of PDT to inhibit M in injured arteries may be based not only on the use of divergent protocols, animal models and vessel sizes, but on the different photosensitizer and light dosimetry employed.…”
Section: Introductionmentioning
confidence: 99%
“…The light is then delivered to the treatment site either directly or via hollow wave guides or fibers terminating in optical configurations to achieve either a circumferential, segmental, or conical beam profile. 16 Radially emitting fibers, with a variety of designs, have been used for endovascular PDT in animals, [17][18][19] and in one case, a 2-patient clinical study. 17 Another important advance in photoangioplasty is the development of compact, portable, and relatively inexpensive diode-based lasers to replace the older, large systems requiring special electrical and plumbing infrastructures; the latter are mostly dye lasers pumped by another laser (argon, 19 -21 KTP YAG) or pulse lasers (copper vapor).…”
Section: Mechanism Of Pdt Actionmentioning
confidence: 99%
“…17 Another important advance in photoangioplasty is the development of compact, portable, and relatively inexpensive diode-based lasers to replace the older, large systems requiring special electrical and plumbing infrastructures; the latter are mostly dye lasers pumped by another laser (argon, 19 -21 KTP YAG) or pulse lasers (copper vapor). 19 Severe cellular damage is noted in atheromatous areas after light exposure. 7 However, there is demonstrable preservation of the intact elastic lamina and of normal collagen in the adventitia, suggesting that the functional integrity of the vessel is conserved.…”
Section: Mechanism Of Pdt Actionmentioning
confidence: 99%