Induction of γ‐aminobutyric acid plays a positive role to <i>Arabidopsis</i> resistance against <i>Pseudomonas syringae</i>

Deng, Xiangxiong; Xu, Xuwen; Liu, Yu; Zhang, Yan; Yang, Liuyi; Zhang, Shuqun; Xu, Juan

doi:10.1111/jipb.12974

Cited by 33 publications

(30 citation statements)

References 51 publications

(84 reference statements)

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“…Recently, Deng et al [ 148 ] reported that activation of the mitogen-activated protein kinase (MPK3/MPK6) signaling cascade greatly induces GABA biosynthesis in Arabidopsis ( Table 3 ). The gad1/2/4 triple and gad1/2/4/5 quadruple mutants, in which the GABA levels are extremely low and the Glu and alanine levels are compromised, are more susceptible to both Pst and Pst-avrRpt2.…”

Section: Gaba Metabolism and Its Response To Biotic Stressmentioning

confidence: 99%

γ-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities

Shelp

Aghdam

Flaherty

2021

Plants

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Global climate change and associated adverse abiotic and biotic stress conditions affect plant growth and development, and agricultural sustainability in general. Abiotic and biotic stresses reduce respiration and associated energy generation in mitochondria, resulting in the elevated production of reactive oxygen species (ROS), which are employed to transmit cellular signaling information in response to the changing conditions. Excessive ROS accumulation can contribute to cell damage and death. Production of the non-protein amino acid γ-aminobutyrate (GABA) is also stimulated, resulting in partial restoration of respiratory processes and energy production. Accumulated GABA can bind directly to the aluminum-activated malate transporter and the guard cell outward rectifying K+ channel, thereby improving drought and hypoxia tolerance, respectively. Genetic manipulation of GABA metabolism and receptors, respectively, reveal positive relationships between GABA levels and abiotic/biotic stress tolerance, and between malate efflux from the root and heavy metal tolerance. The application of exogenous GABA is associated with lower ROS levels, enhanced membrane stability, changes in the levels of non-enzymatic and enzymatic antioxidants, and crosstalk among phytohormones. Exogenous GABA may be an effective and sustainable tolerance strategy against multiple stresses under field conditions.

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Section: Gaba Metabolism and Its Response To Biotic Stressmentioning

confidence: 99%

γ-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities

Shelp

Aghdam

Flaherty

2021

Plants

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“…GABA metabolism can coordinate the carbon and nitrogen balance of mitochondrial dysfunction mutant and improve its photosynthetic efficiency under salt stress (Akcay et al 2012). Previous researches have shown that environmental stress promotes the production of GABA in plants and the accumulation of GABA improves tolerance to drought stress (Serraj et al 1998), salt stress (Al-Quraan et al 2013, insect injury (Bown et al 2006) and pathogen infection (Deng et al 2020). In Arabidopsis, GABA can reduce stomatal opening and transpirational water loss by negatively regulating the anion transporter located in the vacuole membrane of stomatal guard cells under drought conditions (Xu et al 2021).Under salt stress, the application of exogenous GABA significantly increased the content of endogenous GABA, enhanced the antioxidant activity and reduced the damage of cell membrane in maize seedlings (Wang et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Exogenous Gamma-aminobutyric Acid Coordinates Active Oxygen and Amino Acid Homeostasis to Enhance Heat Tolerance in Wheat Seedlings

Wang

Peng

et al. 2021

J Plant Growth Regul

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Heat stress has detrimental impacts on wheat growth and yield formation. Conferring heat tolerance through applying plant growth regulators is a feasible strategy to reduce loss. Gamma aminobutyric acid (GABA) is a four-carbon non-proteinogenic amino acid existing in organisms and accumulates in response to stress. In this study, spring wheat Liaochun17 and winter wheat Jingdu 40 were used to investigate the function of exogenous GABA on the heat tolerance of wheat seedlings. Data displayed that GABA treatment not only reduced the production of reactive active oxygen (ROS), but also improved the scavenging capacity of diphenyl picryl phenyl hydrazine active oxygen under heat stress, thus alleviating the accumulation of malondialdehyde and the damage of cell membrane. In addition, analysis of protein and amino acids revealed that GABA effectively promoted the accumulation of soluble protein and coordinated amino acid homeostasis. Summarily, our current findings revealed that GABA strengthened the resistance of wheat seedling to heat stress by maintaining the metabolism balance of ROS and amino acids.

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“…Among MAPK proteins, MPK3 and MPK6, together with their upstream MAPKKs, MKK4 and MKK5, are involved in a number of biological processes. They are implicated in plant innate immunity (Asai et al, 2002), stomatal patterning (Wang et al, 2007), floral organ abscission and lateral root formation (Cho et al, 2008;Zhu et al, 2019), ovule development (Wang et al, 2008), and plant defense (; Deng et al, 2020;Yang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

RGF1-RGI1, a Peptide-Receptor Complex, Regulates Arabidopsis Root Meristem Development via a MAPK Signaling Cascade

Shi

et al. 2020

Molecular Plant

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Root growth is maintained by the continuous division of cells in the apical meristem. ROOT MERISTEM GROWTH FACTOR 1 (RGF1) is a critical peptide hormone regulating root stem cell niche maintenance. Previous studies discovered that five closely related leucine-rich repeat receptor-like protein kinases (LRR-RLKs), named RGF1 INSENSITIVES (RGIs) or RGF1 RECEPTORS (RGFRs), are able to perceive the RGF1 signal and redundantly control root stem cell niche maintenance. RGF1 regulates root meristem activity mainly via two downstream transcription factors, PLETHORA 1 (PLT1) and PLT2. Regulatory proteins connecting cell surface RGF1-RGI1 and nuclear PLTs, however, were not identified. Here, we report that the mitogen-activated protein (MAP) kinase kinase 4 (MKK4) and MAP kinase 3 (MPK3) were coimmunoprecipitated with RGI1-FLAG after Arabidopsis seedlings were treated with RGF1. Genetic and biochemical assays confirmed that MKK4 and MKK5, and their downstream targets MPK3 and MPK6, are essential RGI-dependent regulators of root meristem development. In addition, we found that the MKK4/MKK5-MPK3/MPK6 module functions downstream of YDA, a MAPKKK. Our results demonstrate that RGF1-RGI1 regulate the expression of PLT1/PLT2 via a YDA-MKK4/MKK5-MPK3/MPK6 signaling cascade.

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Induction of γ‐aminobutyric acid plays a positive role to Arabidopsis resistance against Pseudomonas syringae

Cited by 33 publications

References 51 publications

γ-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities

γ-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities

Exogenous Gamma-aminobutyric Acid Coordinates Active Oxygen and Amino Acid Homeostasis to Enhance Heat Tolerance in Wheat Seedlings

RGF1-RGI1, a Peptide-Receptor Complex, Regulates Arabidopsis Root Meristem Development via a MAPK Signaling Cascade

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