Induction of Vasodilation by Hydrogen Peroxide and Its Application in Exercise Science

Sung, Dong Jun; So, Wi-Young; Ryu, Ho-Young; An, Hyun-Sung; Cha, Kwang-Suk

doi:10.5604/20831862.988882

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be noted that a delayed increase in T-lymphocytes (CD4 + ) was found in the blood of patients taking EchA [82]. Hydrogen peroxide and nitric oxide (NO), formed in endothelial and smooth muscle vascular cells after treatment with EchA, cause vasodilation and reduce ischemia and hypoxia [83].…”

Section: Discussionmentioning

confidence: 99%

Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets

Artyukov

Zelepuga

Bogdanovich

et al. 2020

JCM

View full text Add to dashboard Cite

The effect of low doses of echinochrome A (EchA), a natural polyhydroxy-1,4-naphthoquinone pigment from the sea urchin Scaphechinus mirabilis, has been studied in clinical trials, when it was used as an active substance of the drug Histochrome® and biologically active supplement Thymarin. Several parameters of lipid metabolism, antioxidant status, and the state of the immune system were analyzed in patients with cardiovascular diseases (CVD), including contaminating atherosclerosis. It has been shown that EchA effectively normalizes lipid metabolism, recovers antioxidant status and reduces atherosclerotic inflammation, regardless of the method of these preparations’ administrations. Treatment of EchA has led to the stabilization of patients, improved function of the intracellular matrix and decreased epithelial dysfunction. The increased expression of surface human leukocyte antigen DR isotype (HLA-DR) receptors reflects the intensification of intercellular cooperation of immune cells, as well as an increase in the efficiency of processing and presentation of antigens, while the regulation of CD95 + expression levels suggests the stimulation of cell renewal processes. The immune system goes to a different level of functioning. Computer simulations suggest that EchA, with its aromatic structure of the naphthoquinone nucleus, may be a suitable ligand of the cytosolic aryl cell receptor, which affects the response of the immune system and causes the rapid expression of detoxification enzymes such as CYP and DT diaphorase, which play a protective role with CVD. Therefore, EchA possesses not only an antiradical effect and antioxidant activity, but is also a SOD3 mimetic, producing hydrogen peroxide and controlling the expression of cell enzymes through hypoxia-inducible factors (HIF), peroxisome proliferator-activated receptors (PPARs) and aryl hydrocarbon receptor (AhR).

show abstract

Section: Discussionmentioning

confidence: 99%

Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets

Artyukov

Zelepuga

Bogdanovich

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…In humans, EchA showed nitric-oxide- and hydrogen-peroxide-mimicking effects in endothelial and smooth muscle vascular cells. This generated vasodilation and reduced ischemia and hypoxia [ 12 , 44 ].…”

Section: Echinochrome a And Redox Imbalancementioning

confidence: 99%

“…This is due to its ability to neutralize ROS, chelate metals, and serve as an intracellular messenger, promoting hydroperoxides decomposition, avoiding lipid peroxidation, and increasing GSH production. As a consequence, mitochondria perform better, and the oxygen and ATP levels increase in the cell [ 12 , 21 , 43 , 44 ]. In summary, EchA acts as a primary antioxidant by attacking superoxides, but also works as a secondary antioxidant by increasing the hydrogen peroxide level, mimicking the SOD enzyme, and triggering the GSH pathway ( Figure 2 ).…”

Section: Echinochrome a And Redox Imbalancementioning

confidence: 99%

“…However, current clinical evidence indicates that its bioavailability is low [ 80 ]. Considering all these factors, EchA may play a crucial role in CSS treatment as one of its most important characteristics is that it can increase GSH metabolism and, as such, prevent the GSH depletion found in CSS patients [ 3 , 12 , 21 , 22 , 30 , 43 , 44 ].…”

Section: Echinochrome a And Cytokine Storm Syndromementioning

confidence: 99%

See 1 more Smart Citation

Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome

et al. 2021

View full text Add to dashboard Cite

Background: Echinochrome A (EchA) is a pigment from sea urchins. EchA is a polyhydroxylated 1,4-naphthoquinone that contains several hydroxyl groups appropriate for free-radical scavenging and preventing redox imbalance. EchA is the most studied molecule of this family and is an active principle approved to be used in humans, usually for cardiopathies and glaucoma. EchA is used as a pharmaceutical drug. Methods: A comprehensive literature and patent search review was undertaken using PubMed, as well as Google Scholar and Espacenet search engines to review these areas. Conclusions: In the bloodstream, EchA can mediate cellular responses, act as a radical scavenger, and activate the glutathione pathway. It decreases ROS imbalance, prevents and limits lipid peroxidation, and enhances mitochondrial functions. Most importantly, EchA contributes to the modulation of the immune system. EchA can regulate the generation of regulatory T cells, inhibit pro-inflammatory IL-1β and IL-6 cytokine production, while slightly reducing IL-8, TNF-α, INF-α, and NKT, thus correcting immune imbalance. These characteristics suggest that EchA is a candidate drug to alleviate the cytokine storm syndrome (CSS).

show abstract

Polish bibliography of occupational medicine, 2012

Kowalczyk¹

2013

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

show abstract

Induction of Vasodilation by Hydrogen Peroxide and Its Application in Exercise Science

Cited by 3 publications

References 0 publications

Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets

Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets

Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome

Polish bibliography of occupational medicine, 2012

Contact Info

Product

Resources

About