Induction of uterine hyperplasia after cafeteria diet exposure

Gastiazoro, María Paula; Guerrero-Schimpf, Marlise; Durando, Milena; Lazzarino, Gisela Paola; Andreoli, María Florencia; Zierau, Oliver; Luque, Enrique H.; Ramos, Jorge G.; Varayoud, Jorgelina

doi:10.1016/j.mce.2018.06.007

Cited by 3 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CAF diet also results in alterations of metabolic profile, induces lipogenesis and decreases very-low-density lipoprotein (VLDL) export leading to lipid accumulation in the liver and hepatic steatosis 26 – 29 . These changes are accompanied by increased concentrations of cholesterol, glucose, and triacylglycerol in blood 24 , 30 – 32 . Finally, CAF diet leads to abdominal and visceral fat accumulation and insulin resistance 24 , 27 , 30 .…”

Section: Introductionmentioning

confidence: 99%

“…These changes are accompanied by increased concentrations of cholesterol, glucose, and triacylglycerol in blood 24 , 30 – 32 . Finally, CAF diet leads to abdominal and visceral fat accumulation and insulin resistance 24 , 27 , 30 . In animal models, similar to situation observed in obese individuals, CAF diet-induced obesity results in inflammation 25 , 33 , 34 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Matuszewska

Zalewski

Klimaszyk

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Abstract“Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet in animals, a cafeteria (CAF) diet is used. We hypothesized that CAF diet given to rats before, and during pregnancy and lactation differently influences fat content, metabolic and inflammation profiles in offspring. Females were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25), body composition, fat contents were measured, and blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet lead to sex-specific alterations in offspring. At PND25, CAF offspring had: (1) higher percentage of fat content, and were lighter; (2) sex-specific differences in levels of glucose; (3) higher levels of interleukin 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); (4) sex-specific differences in concentration of IL-6 and TNF-α, with an increase in CAF females; (5) higher level of IL-10 in both sexes, with a more pronounced increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Matuszewska

Zalewski

Klimaszyk

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…These changes are accompanied by increased concentrations of cholesterol, glucose, and triacylglycerol in blood 24,30−32 . Finally, CAF diet leads to abdominal and visceral fat accumulation and insulin resistance 24,27,30 . In animal models, similar to situation in obese individuals, CAF diet-induced obesity results in in ammation 25,33,34 .…”

Section: Introductionmentioning

confidence: 99%

Mothers cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rats offspring

Matuszewska

Zalewski

Klimaszyk

et al. 2021

Preprint

View full text Add to dashboard Cite

“Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributing to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet, in animals cafeteria (CAF) diet is used. We hypothesis that CAF diet given to rats before, during pregnancy and lactation differently influence fat content, metabolic and inflammation profiles in offspring. Female were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25) body composition, fat contents were measured, blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet leaded to sex-specific alterations in offspring. At PND25, CAF offspring had: 1) higher percentage of fat content and were lighter; 2) sex-specific differences in levels of glucose; 3) higher levels of interleukins 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); 4) sex-specific differences in concentration of IL-6 and TNF-α, with increase in CAF females; 5) higher level of IL-10 in both sex, with bigger increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.

show abstract

Fat augments leptin-induced uterine contractions by decreasing JAK2 and BKCa channel expressions in late pregnant rats

Pavithra

Ramesh²,

Panigrahi³

et al. 2022

Cytokine

View full text Add to dashboard Cite

Induction of uterine hyperplasia after cafeteria diet exposure

Cited by 3 publications

References 48 publications

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Mothers cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rats offspring

Fat augments leptin-induced uterine contractions by decreasing JAK2 and BKCa channel expressions in late pregnant rats

Contact Info

Product

Resources

About